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The relation between intraoperative ocular fundus blood flow and cerebral circulation during cardiovascular surgery

Research Project

Project/Area Number 16K19961
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular surgery
Research InstitutionAsahikawa Medical College

Principal Investigator

Kimura Fumiaki  旭川医科大学, 医学部, 助教 (20516413)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords心臓血管外科 / 脳循環 / 眼底血流 / 大動脈外科 / 脳保護 / 循環器
Outline of Final Research Achievements

Laser speckle flowgraphy (LSFG) is a novel technology to evaluate the blood flow of the optic nerve head. We have focused on the potential of the LSFG as a new method of neuro-monitoring. LSFG is a novel technology and a noninvasive quantitative method for determining ocular blood flow. Our study revealed the retinal blood flow has a potential to be a reliable monitor of cerebral blood flow during cardiovascular surgery.
Our study has unique and original viewpoints at the relation cerebral circulation and ocular fundus blood flow. These findings from our study are very important. Therefore, we reported 2 international conference presentations, and published 4 English papers.

Academic Significance and Societal Importance of the Research Achievements

本研究では、レーザースペックル法による眼底血流測定で心大血管手術時の眼底血流量と脳循環動態との関係を解明し、さらに実臨床での術中脳循環モニタリングの新手法として確立されることを期待される。また、心臓血管外科手術時における脳灌流量の最適化を行うことで、より効果的な脳保護法の構築が可能となり、重篤な術後合併症である脳神経合併症を減少させることが期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2018 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Cerebral Circulation During Retrograde Cerebral Perfusion: Evaluation Using Laser Speckle Flowgraphy2018

    • Author(s)
      Kanda Hirotsugu、Kunisawa Takayuki、Iida Takafumi、Tada Masahiro、Kimura Fumiaki、Ise Hayato、Kamiya Hiroyuki
    • Journal Title

      The Annals of Thoracic Surgery

      Volume: - Issue: 6 Pages: 1747-1752

    • DOI

      10.1016/j.athoracsur.2018.11.067

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebral circulation estimated by laser speckle flowgraphy in2017

    • Author(s)
      Hiroto Kitaharaa
    • Journal Title

      Interactive CardioVascular and Thoracic Surgery

      Volume: 印刷中 Issue: 1 Pages: 25-29

    • DOI

      10.1093/icvts/ivx046

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Evaluation of cerebral circulation during retrograde perfusion by laser speckle flowgraphy2016

    • Author(s)
      Fumiaki Kimura
    • Journal Title

      General Thoracic and Cardiovascular Surgery

      Volume: 印刷中 Issue: 9 Pages: 527-531

    • DOI

      10.1007/s11748-016-0727-z

    • NAID

      120006334807

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined Use of Intra-aortic Balloon Pump and Venoarterial Extracorporeal Membrane Oxygenation Support With Femoral Arterial Cannulation Impairs Cerebral Microcirculation: Evaluation With Laser Speckle Flowgraphy2016

    • Author(s)
      Hirotsugu Kanda,
    • Journal Title

      The Journal of Cardiothoracic and Vascular Anesthesia

      Volume: 印刷中 Issue: 3 Pages: 1021-1024

    • DOI

      10.1053/j.jvca.2016.09.012

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Novel Evaluation Method of Cerebral Microcirculation during hypothermic circulatory arrest using Laser Speckle Flowgraphy: A Pilot Study2016

    • Author(s)
      Fumiaki Kimura
    • Organizer
      2016International Society for Minimally Invasive Cardiothoracic Surgery
    • Place of Presentation
      Montréal Québec
    • Year and Date
      2016-06-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] UTILITY OF OCULAR FUNDUS BLOOD FLOW MEASUREMENT WITH LASER SPECKLE FLOWGRAPHY: A PILOT STUDY IN CARDIAC SURGERY2016

    • Author(s)
      Fumiaki Kimura
    • Organizer
      the 24th Annual Meeting of Asian Society for Cardiovascular and Thoracic Surgery
    • Place of Presentation
      Taipei
    • Year and Date
      2016-04-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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