| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Expression of an capelin receptor, APJ, in peripheral blood mononuclear cell (PBMNC) isolated from young mice was increased by hypoxic preconditioning but not from old mice. Apelin did not up regulate expression of PDGF-BB and TGF-β in hypoxic PBMNCs isolated from old mice. Furthermore, proliferation of aged vascular smooth muscle cells treated with apelin was not accelerated in the presence of PDGF-BB unlike normal vascular smooth muscle cells.
These results suggested that apelin mediated responses were decreased in aged cells. And it was also suggested that the synergistic neovascular maturation effect via PDGF signaling in combinatorial treatment of hypoxic preconditioned PBMNCs with apelin may not be sufficiently showed in elderly patients.
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