Spasticity reduction trial by caveolin 1 over-expression therapy; Rat ischemic paraplegia model

Research Project

Project/Area Number	16K19969
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Cardiovascular surgery
Research Institution	University of the Ryukyus
Principal Investigator	Kamizato Kota 琉球大学, 医学(系)研究科(研究院), 助教 (10554454)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	対麻痺 / カベオリン / 痙性麻痺 / 虚血性脊髄障害 / カベオリン１ / アデノ随伴ウイルス
Outline of Final Research Achievements	Rat motor dysfunction model (hind-limb paraplegia model) were chosen in our study. Neuro growth factor (caveolin 1) were provided to remaining neurons by intracellar caveolin production. Subpial injection was used for virus delivery. It is new and efficient method for gene delivery. Axonal grow from remained neurons were confirmed. We can not show motor recovery with caveolin over expression in rat paraplegia model.

Report

(3 results)