Development of minimally invasive treatment for in-stent restenosis prevention by free radicals.

• Project/Area Number: 16K19971
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular surgery
• Research Institution: Keio University
• Principal Investigator: HAYASHI KEITA 慶應義塾大学, 医学部(信濃町), 助教 (80770859)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 血管内治療 / 末梢動脈疾患 / ステント内再狭窄 / フリーラジカル / 超音波 / 金属ステント / 生体吸収性ステント / 末梢血管疾患

Outline of Final Research Achievements

The aim of this study is to develop minimally invasive treatment for preventing in-stent restenosis of peripheral artery disease. An in vitro study, we confirmed excitation of nitinol and inhibitory effect of vascular smooth muscle cell proliferation by ultrasonic exposure. Furthermore, we conducted a study to comparison long-term vascular morphological changes between bioresorbable scaffolds and bare metal stents in porcine iliac artery. In this result, we found that the rate of stenosis of bare metal stents increased over time. In contrast, bioabsorbable scaffolds showed maximal stenosis at 6 weeks after placement and the stenosis gradually improved thereafter.

Academic Significance and Societal Importance of the Research Achievements

本研究で得た、ミニブタ正常血管に金属ステントと生体吸収性ステントを長期留置した際の研究データは、後に予定しているミニブタ頸動脈へのステント留置や超音波照射によるステント狭窄予防の研究、また金属ステントや生体吸収性ステントを基盤とした新たな医療機器開発の研究におけるコントロールデータとして広く有用が可能だと考える。