Study on lung cancer immunotherapy incorporating inhibition of derivation of CAFs progenitor from bone marrow

Research Project

Project/Area Number	16K19977
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Respiratory surgery
Research Institution	Shiga University of Medical Science
Principal Investigator	Ohshio Yasuhiko 滋賀医科大学, 医学部, 助教 (60731916)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000) Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	がん間質細胞 / CCL2 / アンジオテンシン2受容体拮抗薬 / 癌
Outline of Final Research Achievements	CAFs in lung cancer tissue were increased in COPD. The degree of emphysematous change would be more related by the frequency of CAFs. Among the various COPD parameters, LAA would be more related to the number of CAFs in tumor microenvironment. Because parameters obtained from the pulmonary function test and smoking index are often affected by the skill and memory of the patients, LAA might be more reliable to predict the frequency of CAFs. These results suggested that intervention in COPD might be one of the CAFs targeted strategies.