Thermographical evaluation to detect graft damage.

• Project/Area Number: 16K19978
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Kyoto University
• Principal Investigator: Motoyama Hideki 京都大学, 医学研究科, 特定病院助教 (20762264)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肺移植 / 体外肺潅流 / 障害肺 / 局所障害 / サーモグラフィー / 肺体外潅流 / Ex Vivo Lung Perfusion / graft dysfunction / ドナー肺

Outline of Final Research Achievements

Experiment 1: To evaluate grafts using thermography, the beagle dogs were divided into the control, malperfusion and edema group. In the malperfusion group, the left lower artery was clamped. In the edema group, the edema was set in the left lower lobe by a saline injection method. Thermography revealed that the temperature of the malperfusion area was significantly lower than that of the normal area. The surface temperature change of the edema group was slower than that of the control group. Thermography could distinguish the three groups.

Research Products

• [Journal Article] Inhibition of Toll-like recetor 4 signaling ameliorates lung ischemia-reperfusion injury in acute hyperglycemic conditions. (2016)
  • Author(s): Takahashi M, Chen-Yoshikawa TF, Menju T, Ohata K, Kondo T, Motoyama H, Hijiya K, Aoyama A, Date H.
  • Journal Title: J Heart Lung Transplant Volume: 35(6) Pages: 815-22
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vascular endothelial-cadherin expression after reperfusion correlates with lung injury in rat lung transplantation. (2016)
  • Author(s): ka S, Chen-Yoshikawa TF, Miyamoto E, Takahashi M, Ohata K, Kondo T, Hijiya K, Motoyama H, Aoyama A, Date H.
  • Journal Title: Ann Thorac Surg Volume: 101(6) Pages: 2161-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bronchodilator inhalation during ex vivo lung perfusion improves posttransplant graft function after warm ischemia. (2016)
  • Author(s): Hijiya K, Chen-Yoshikawa TF, Kondo T, Motoyama H, Ohsumi A, Nakajima D, Sakamoto J, Ohata K, Takahashi M, Tanaka S, Miyamoto E, Aoyama A, Date H.
  • Journal Title: Ann Thorac Surg Volume: -
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Protective effects of Imatinib on ischemia/reperfusion injury in rat lung. (2016)
  • Author(s): Tanaka S, Chen-Yoshikawa TF, Kajiwara M, Menju T, Ohata K, Takahashi M, Kondo T, Hijiya K, Motoyama H, Aoyama A, Masuda S, Date H.
  • Journal Title: Ann Thorac Surg Volume: 102(5) Pages: 1717-1724
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Outcomes of various transplant prodedures (single, sparing, inverted) in living-donor lobar lung transplantation. (2016)
  • Author(s): Date H, Aoyama A, Hijiya K, Motoyama H, Handa T, Kinoshita H, Baba S, Mizota T, Minakata K, Chen-Yoshikawa TF.
  • Journal Title: J Thorac Cardiovasc Surg Volume: -
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Immune function monitoring in lung transplantation using adenosine triphosphate production: time trends and relationship to postoperative infection. (2016)
  • Author(s): Takahashi M, Ohsumi A, Ohata K, Kondo T, Motoyama H, Hijiya K, Aoyama A, Date H, Chen-Yoshikawa TF.
  • Journal Title: Surg Today Volume: -
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Remarks] 京都大学呼吸器外科
  • URL: https://www.thoracic-kyoto-u.gr.jp