SPRED-2 is necessary to protect against lung graft injury after mouse lung transplantation

• Project/Area Number: 16K19980
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Okayama University
• Principal Investigator: SHINJI OTANI 岡山大学, 大学病院, 助教 (10770779)
• Research Collaborator: Hashimoto Kohei
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 肺移植 / SPRED2 / 虚血再灌流障害 / MAPK/ERK経路 / マウス / MAPK / 移植・再生医療

Outline of Final Research Achievements

Our study was aimed at examining the role of the Sprouty-related EVH1-domain-containing (SPRED) 2 in Ischemia-reperfusion injury (IRI) in mice that received orthotopic lung transplantation.We suggest that focused treatments suppressing the activity of the MAPK/ERK pathway in transplantation recipients could be effective for the prevention of lung IRI.

Academic Significance and Societal Importance of the Research Achievements

本研究により虚血再灌流障害のメカニズムを解明してそれを抑制することが出来れば，実臨床における肺移植成績を向上させることができ，大変有益であると考える．

Research Products

• [Presentation] SPRED-2 is necessary to protect against lung graft injury after mouse lung transplantation (2018)
  • Author(s): 橋本好平
  • Organizer: The International Society for Heart and Lung Transplantation
  • Int'l Joint Research
• [Presentation] Spred-2 is necessary to protect against lung graft injury after mouse lung transplantation (2018)
  • Author(s): K Hashimoto et al
  • Organizer: International Society for Heart and Lung Transplantation
  • Int'l Joint Research