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Development of a novel surgical marking method using low power laser light.

Research Project

Project/Area Number 16K19986
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory surgery
Research InstitutionTokyo Medical University

Principal Investigator

OHTANI KEISHI  東京医科大学, 医学部, 客員講師 (70384956)

Research Collaborator IKEDA Norihiko  東京医科大学, 医学部, 教授
ARAI Tsunenori  慶應義塾大学, 理工学部物理情報工学科, 教授
MATSUBAYASHI Jun  東京医科大学, 医学部, 准教授
SACHIO Maehara  東京医科大学, 医学部, 助教
IMAI Kentaro  東京医科大学, 医学部, 助教
KUDO Yujin  東京医科大学, 医学部, 助教
ONO Syotaro  東京医科大学, 医学部, 助教
NAGASE Kumiko  東京医科大学, 医学部, 研究助手
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺癌 / 小型肺癌 / レーザー / 術中マーキング / 末梢小型肺癌 / 術前マーキング
Outline of Final Research Achievements

Small lung nodules in peripheral lung are difficult to identify during surgery. Therefore, we developed a new safe and reliable intraoperative marking method using a low power laser light. It irradiated close to the lesion from a bronchus, the site of the lesion can be identified from the lung surface.
We conducted an animal experiment and were able to observe the laser light irradiated in bronchus from the lung surface until the depth of 2cm from pleura. We also could observe the laser light until the depth of 1cm from pleura in human resected lung. Any damages were not detected in the lung around the laser irradiated area in pathological findings.
It might be possible to confirm the localization of small nodules in peripheral lung safely using low power laser light during surgery.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2017

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Skin fluorescence following photodynamic therapy with NPe6 photosensitizer2017

    • Author(s)
      Keishi Ohtani, Jitsuo Usuda, Emiyu Ogawa, Sachio Maehara, Kentaro Imai, Yujin Kudo, Shotaro Ono, Shunsuke Shigefuku, Daisuke Eriguchi, Tatsuya Inoue, Junichi Maeda, Koichi Yoshida, Masaru Hagiwara, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Tsunenori Arai, Norihiko Ikeda
    • Journal Title

      Photodiagnosis and Photodynamic Therapy

      Volume: 20 Pages: 210-214

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Presentation] 術中レーザーマーキング法の開発2017

    • Author(s)
      大谷 圭志
    • Organizer
      第40回日本呼吸器内視鏡学会学術集会
    • Place of Presentation
      長崎ブリックホール(長崎県長崎市)
    • Year and Date
      2017-06-09
    • Related Report
      2016 Research-status Report
  • [Presentation] 低出力レーザーを用いた新規術中マーキング法の開発2017

    • Author(s)
      大谷 圭志、前原 幸夫、今井健太郎、小野祥太郎、古本 秀行、萩原 優、垣花 昌俊 岡野 哲也、梶原 直央、大平 達夫、池田 徳彦
    • Organizer
      第70回日本胸部外科学会定期学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Development of a novel surgical marking method using low power laser light.2017

    • Author(s)
      Keishi Ohtani, Sachio Maehara, Kentaro Imai, Hideyuki Furumoto, Masaru Hagiwara, Tetsuya Okano, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
    • Organizer
      The 18th World Conference on Lung Cancer
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2019-03-29  

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