Development of a novel surgical marking method using low power laser light.

• Project/Area Number: 16K19986
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory surgery
• Research Institution: Tokyo Medical University
• Principal Investigator: OHTANI KEISHI 東京医科大学, 医学部, 客員講師 (70384956)
• Research Collaborator: IKEDA Norihiko 東京医科大学, 医学部, 教授 ; ARAI Tsunenori 慶應義塾大学, 理工学部物理情報工学科, 教授 ; MATSUBAYASHI Jun 東京医科大学, 医学部, 准教授 ; SACHIO Maehara 東京医科大学, 医学部, 助教 ; IMAI Kentaro 東京医科大学, 医学部, 助教 ; KUDO Yujin 東京医科大学, 医学部, 助教 ; ONO Syotaro 東京医科大学, 医学部, 助教 ; NAGASE Kumiko 東京医科大学, 医学部, 研究助手
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 肺癌 / 小型肺癌 / レーザー / 術中マーキング / 末梢小型肺癌 / 術前マーキング

Outline of Final Research Achievements

Small lung nodules in peripheral lung are difficult to identify during surgery. Therefore, we developed a new safe and reliable intraoperative marking method using a low power laser light. It irradiated close to the lesion from a bronchus, the site of the lesion can be identified from the lung surface.
We conducted an animal experiment and were able to observe the laser light irradiated in bronchus from the lung surface until the depth of 2cm from pleura. We also could observe the laser light until the depth of 1cm from pleura in human resected lung. Any damages were not detected in the lung around the laser irradiated area in pathological findings.
It might be possible to confirm the localization of small nodules in peripheral lung safely using low power laser light during surgery.

Research Products

• [Journal Article] Skin fluorescence following photodynamic therapy with NPe6 photosensitizer (2017)
  • Author(s): Keishi Ohtani, Jitsuo Usuda, Emiyu Ogawa, Sachio Maehara, Kentaro Imai, Yujin Kudo, Shotaro Ono, Shunsuke Shigefuku, Daisuke Eriguchi, Tatsuya Inoue, Junichi Maeda, Koichi Yoshida, Masaru Hagiwara, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Tsunenori Arai, Norihiko Ikeda
  • Journal Title: Photodiagnosis and Photodynamic Therapy Volume: 20 Pages: 210-214
  • Peer Reviewed
• [Presentation] 術中レーザーマーキング法の開発 (2017)
  • Author(s): 大谷 圭志
  • Organizer: 第40回日本呼吸器内視鏡学会学術集会
  • Place of Presentation: 長崎ブリックホール（長崎県長崎市）
  • Year and Date: 2017-06-09
• [Presentation] 低出力レーザーを用いた新規術中マーキング法の開発 (2017)
  • Author(s): 大谷 圭志、前原 幸夫、今井健太郎、小野祥太郎、古本 秀行、萩原 優、垣花 昌俊 岡野 哲也、梶原 直央、大平 達夫、池田 徳彦
  • Organizer: 第70回日本胸部外科学会定期学術集会
• [Presentation] Development of a novel surgical marking method using low power laser light. (2017)
  • Author(s): Keishi Ohtani, Sachio Maehara, Kentaro Imai, Hideyuki Furumoto, Masaru Hagiwara, Tetsuya Okano, Masatoshi Kakihana, Naohiro Kajiwara, Tatsuo Ohira, Norihiko Ikeda
  • Organizer: The 18th World Conference on Lung Cancer
  • Int'l Joint Research