| Project/Area Number |
16K19991
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Hokkaido University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
ISHI Yukitomo 北海道大学, 医学院, 大学院生
KO Suken 北海道大学, 医学院, 大学院生
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Keywords | gene expression analysis / グリオーマ / 包括的遺伝子解析 / メチオニン / マイクロRNA / 神経膠腫 / 脳神経疾患 |
|---|
| Outline of Final Research Achievements |
Gliomas usually show high uptake of methionine in Positron Emission Tomography, but the mechanism of methionine uptake remain unknown. We explored these mechanism through gene expression analysis including microRNA. At the same time, we also investigated the correlation between various somatic mutations of gliomas and clinical information, such as intraoperative fluorescence status of phododynamic diagnosis, MRI appearance, and prognosis using gene expression analysis. In result, we could not identify the specific molecule in methionine uptake of glioma, but we could identify potentially important two molecules in gliomas; 1) PEPT2, which may have important role in the intratumoral fluorescence in glioma photodynamic diagnosis using 5-ALA, and 2) CDKN2A, which may be one of the key gene of the prognosis on glioma with BRAF somatic mutation.
|
