| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
In the present study, we conducted an investigation into the effect of cilostazol on the phosphorylation of heat shock protein 27 (HSP27) and the release of platelet factor 4 and soluble CD 40ligand from collagen-activated platelets in type 2 diabetes mellitus (DM) patients.
It was demonstrated that the rate of platelet aggregation was reduced up to 1.0 micro M, and the levels of phosphorylated-HSP27 (Ser-78 and Ser-82) were also attenuated after cilostazol adminstration.The released platelet factor 4 and soluble CD 40ligand levels from collagen-stimulated platelets were reduced by administration of cilostazol. These results strongly suggest that cilostazol inhibit collagen-induced activation of platelets through attenuation of phosphorylated-HSP27 and release of platelet factor 4 and soluble CD 40ligand in type 2 DM patients.
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