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The effect of cilostazol on thrombosis and atherosclerosis in DM patients

Research Project

Project/Area Number 16K20002
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionGifu University

Principal Investigator

Miyai Masafumi  岐阜大学, 医学部附属病院, 医員 (60613502)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsシロスタゾール / 糖尿病 / 血小板活性化 / 血小板凝集能検査 / 動脈硬化
Outline of Final Research Achievements

In the present study, we conducted an investigation into the effect of cilostazol on the phosphorylation of heat shock protein 27 (HSP27) and the release of platelet factor 4 and soluble CD 40ligand from collagen-activated platelets in type 2 diabetes mellitus (DM) patients.
It was demonstrated that the rate of platelet aggregation was reduced up to 1.0 micro M, and the levels of phosphorylated-HSP27 (Ser-78 and Ser-82) were also attenuated after cilostazol adminstration.The released platelet factor 4 and soluble CD 40ligand levels from collagen-stimulated platelets were reduced by administration of cilostazol. These results strongly suggest that cilostazol inhibit collagen-induced activation of platelets through attenuation of phosphorylated-HSP27 and release of platelet factor 4 and soluble CD 40ligand in type 2 DM patients.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2018 2017 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Remarks (1 results)

  • [Journal Article] Optimal platelet function test for in-stent tissue protrusion following carotid artery stenting2018

    • Author(s)
      Tsujimoto Masanori、Enomoto Yukiko、Miyai Masafumi、Egashira Yusuke、Iwama Toru
    • Journal Title

      Journal of International Medical Research

      Volume: 印刷中 Issue: 5 Pages: 1866-1875

    • DOI

      10.1177/0300060518762949

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current trends in mouse models of glioblastoma2017

    • Author(s)
      Miyai Masafumi、Tomita Hiroyuki、Soeda Akio、Yano Hirohito、Iwama Toru、Hara Akira
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 135 Issue: 3 Pages: 423-432

    • DOI

      10.1007/s11060-017-2626-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Remarks] 岐阜大学医学部脳神経外科

    • URL

      http://www.med.gifu-u.ac.jp/neurosurgery/

    • Related Report
      2017 Annual Research Report 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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