| Project/Area Number |
16K20013
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Hiroshima International University (2017)
Ehime University (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 軸索誘導因子 / netrin / 髄芽腫 / 転移 / 血管新生 / 癌幹細胞 / Shh |
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| Outline of Final Research Achievements |
Netrin-1, a chemoattractant factor in the neuronal system, promotes tumor progression by enhancing angiogenesis and metastasis. Our recent studies demonstrate that netrin-1 promotes medulloblastoma (MB) cell invasiveness and angiogenesis, therefore, we aim to target netrin-1 signaling for MB therapy.
Netrin-1 acts via several receptors, including UNC5A-D, DCC, DSCAM and neogenin. To identify the key netrin receptor in MB, we purified MB cancer stem like cells and carried out microarray. As a result, one of the netrin receptor was elevated in MB cancer stem cells. We will investigate the function of this receptor in MB and expect this receptor as a novel marker of MB stem cell. We will also screen the inhibitor of this receptor and test with MB model mice.
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