Functional analysis of NG2 positive microglia at the periphery of cerebral infarction and its application to cerebral infarction therapy
| Project/Area Number |
16K20014
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脳虚血 / マイクログリア / 神経細胞死 / 脳梗塞 / アポトーシス / 脳神経疾患 |
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| Outline of Final Research Achievements |
Activated microglia present at the periphery of cerebral infarction surround and phagocytose degenerating and apoptotic neurons. The mRNAs of MFG-E8, MerTK, Gas6, Protein S, complement (C1q, C3) related to phagocytosis of apoptotic cells of TREM2 and eat-me signal are elevated at the periphery of the cerebral infarction. In the immunohistochemical staining, activated microglia had CD68 positive phagosome and adhered to C3, ProteinS positive Neuron. It was suggested that microglia selectively phagocytizes neurons via these phagocytosis - related molecules, suggesting the possibility of being a target to suppress slow nerve cell death.
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Report
(3 results)
Research Products
(6 results)
