| Project/Area Number |
16K20019
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurosurgery
|
|---|
| Research Institution | Yokohama City University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
ICHIMURA Koichi
YAMASHITA Satoshi
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
|---|
| Keywords | PCNSL / DLBCL / CpG island / DNA methylation / CpGアイランド / DNAメチル化 / 中枢神経系原発悪性リンパ腫 / びまん性大細胞型B細胞リンパ腫 / Methylation / epigenome |
|---|
| Outline of Final Research Achievements |
Based on the notion that DNA methylation profiles better represent the underlying biology of cells, we performed a 450K methylation analysis in a large series of PCNSL and compared with that of systemic DLBCLs. Our results showed that PCNSL have distinct DNA methylation profiles compared with systemic DLBCLs, while a subset of systemic DLBCL shared a similar methylation profile with PCNSL, suggesting that PCNSL may have developed from those DLBCL that acquired hypermethylation and higher affinity in CNS. We propose that PCNSL originates from mature B cells outside CNS and belongs to a distinct lymphoma entity from the majority of systemic DLBCL. This report was accepted for publication in Acta Neuropathologica (IF 12.213 2016/2017) (Accepted: 24 December 2016 / Published online: 5 January 2017).
|
