enome-wide DNA methylation profiling identifies primary central nervous system lymphomas as a distinct entity from systemic diffuse large B-cell lymphomas
| Project/Area Number |
16K20019
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Research Collaborator |
ICHIMURA Koichi
YAMASHITA Satoshi
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | PCNSL / DLBCL / CpG island / DNA methylation / CpGアイランド / DNAメチル化 / 中枢神経系原発悪性リンパ腫 / びまん性大細胞型B細胞リンパ腫 / Methylation / epigenome |
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| Outline of Final Research Achievements |
Based on the notion that DNA methylation profiles better represent the underlying biology of cells, we performed a 450K methylation analysis in a large series of PCNSL and compared with that of systemic DLBCLs. Our results showed that PCNSL have distinct DNA methylation profiles compared with systemic DLBCLs, while a subset of systemic DLBCL shared a similar methylation profile with PCNSL, suggesting that PCNSL may have developed from those DLBCL that acquired hypermethylation and higher affinity in CNS. We propose that PCNSL originates from mature B cells outside CNS and belongs to a distinct lymphoma entity from the majority of systemic DLBCL. This report was accepted for publication in Acta Neuropathologica (IF 12.213 2016/2017) (Accepted: 24 December 2016 / Published online: 5 January 2017).
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Report
(3 results)
Research Products
(2 results)
