Research Project
Grant-in-Aid for Young Scientists (B)
Oxidative stress plays a critical role in the pathogenesis of ischemia/reperfusion (I/R) injury that leads to apoptosis. We previously identified a novel apoptosis inducing humoral factor in a conditioned medium of cardiac myocytes subjected to hypoxia/reoxygenation (H/R). We named this novel post-translationally modified secreted form of eIF5A as Oxidative stress-Responsive Apoptosis Inducing Protein (ORAIP). We confirmed that rat myocardial I/R injury was significantly suppressed by treatment with neutralizing anti-ORAIP monoclonal antibodies (mAbs). The purpose of this study is to investigate whether the same mechanism is involved in cerebral I/R injury. We found the expression of ORAIP in various types of neural cells in the ischemic penumbra region after cerebral I/R. Anti-ORAIP mAb-treatment also significantly decreased the cerebral infarct volume compared with vehicle-treatment group.
All 2018 2017
All Presentation (5 results) (of which Int'l Joint Research: 2 results)
