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Novel apoptosis-inducing ligand ORAIP plays a critical role in cerebral ischemia/reperfusion injury

Research Project

Project/Area Number 16K20021
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionYokohama City University

Principal Investigator

TAKASE Hajime  横浜市立大学, 医学研究科, 共同研究員 (00549975)

Research Collaborator SUENAGA Jun  
KISHIMOTO Masao  
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords酸化ストレス / アポトーシス / 脳虚血 / 再灌流障害 / ORAIP / apoptosis / oxidative stress / cerebral ischemia / repercussion injury / 脳血管障害学 / 脳保護療法 / 脳梗塞 / 虚血再灌流 / eIF5A
Outline of Final Research Achievements

Oxidative stress plays a critical role in the pathogenesis of ischemia/reperfusion (I/R) injury that leads to apoptosis. We previously identified a novel apoptosis inducing humoral factor in a conditioned medium of cardiac myocytes subjected to hypoxia/reoxygenation (H/R). We named this novel post-translationally modified secreted form of eIF5A as Oxidative stress-Responsive Apoptosis Inducing Protein (ORAIP). We confirmed that rat myocardial I/R injury was significantly suppressed by treatment with neutralizing anti-ORAIP monoclonal antibodies (mAbs). The purpose of this study is to investigate whether the same mechanism is involved in cerebral I/R injury. We found the expression of ORAIP in various types of neural cells in the ischemic penumbra region after cerebral I/R. Anti-ORAIP mAb-treatment also significantly decreased the cerebral infarct volume compared with vehicle-treatment group.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017

All Presentation (5 results) (of which Int'l Joint Research: 2 results)

  • [Presentation] 脳虚血再灌流障害における酸化ストレス応答性アポトーシス誘導因子(ORAIP)の意義2018

    • Author(s)
      岸本真雄、高瀬創、末永潤、荒木孝太、八尾貴子、山本哲哉、世古義規
    • Organizer
      第43回日本脳卒中学会学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 酸化ストレス応答性新規アポトーシス誘導因子(ORIAP)が脳虚血再灌流障害において重要な働きをする2017

    • Author(s)
      岸本真雄 末永潤 高瀬創 荒木孝太 八尾貴子 世古義規
    • Organizer
      第42回 日本脳卒中学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2017-03-16
    • Related Report
      2016 Research-status Report
  • [Presentation] Oxidative stress-Responsive Apoptosis inducing Protein (ORAIP) Plays a Critical Role in Cerebral Ischemia/Reperfusion injury.2017

    • Author(s)
      Kishimoto M, Suenaga J, Takase H, Araki K, Yao T, Seko Y
    • Organizer
      BRAIN & BRAIN PET 2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Oxidative stress-Responsive Apoptosis inducing Protein (ORAIP) Plays a Critical Role in Cerebral Ischemia/Reperfusion injury.2017

    • Author(s)
      Kishimoto M, Suenaga J, Takase H, Araki K, Yao T, Seko Y
    • Organizer
      EANS2017
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳虚血再灌流障害における酸化ストレス応答性アポトーシス誘導因子(ORAIP)の役割およびその機序の解析2017

    • Author(s)
      岸本真雄、末永潤、高瀬創、荒木孝太、八尾貴子、世古義規
    • Organizer
      日本脳神経外科学会第76回学術総会
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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