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Molecular biological study of brain tumors for optimal treatment

Research Project

Project/Area Number 16K20025
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurosurgery
Research InstitutionKeio University

Principal Investigator

Ichimura Saeko  慶應義塾大学, 医学部(信濃町), 共同研究員 (30464952)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords脳腫瘍 / 分子生物学 / 脳神経疾患
Outline of Final Research Achievements

First study included 57 patients with codeleted gliomas. No significant difference was observed in the overall survival of the patients with respect to age, degree of resection, maximum tumor diameter,histological subtype, and MGMT promoter methylation status. Gain of chromosome 19p and grade III histology were associated with shorter OS and they might be negative prognostic factors for the patients with gliomas showing total 1p19q loss.
Second study included 13 patients with brain tumors manifested or progressed during pregnancy. Expression of VEGFR-1/2, EGFR and c-Myc were observed regardless of the stage of pregnancy. Sex hormone receptors and HER-2 were mainly expressed in the tumors progressed during the postpartum. There was no specific CNAs shared between the pregnancy-associated brain tumors. However, it should be noted that an anaplastic astrocytoma with IDH mutation progressed from the precedent grade 2 tumors showed numerous CNAs including amplification of the c-Myc locus.

Academic Significance and Societal Importance of the Research Achievements

1p19q共欠失を持つ神経膠腫について、染色体解析、遺伝子解析などを行い、臨床情報と照らし合わせ、今後の治療方針の決定や経過の推測に有用な情報を得る事を目的とし、研究を行った。Follow-up中央値は約9年と類似の既報告に比べて長く、意義ある報告であったと考えられる。
妊娠に関連して発症(症状が出現)あるいは症状の増悪を認めた脳腫瘍症例は極めて稀であり、現時点でそれらの症例に対し分子生物学的解析を行った国内外での報告は殆どみられない。本研究で得られた知見が将来妊娠中あるいは分娩後に発症した脳腫瘍患者の治療や予後の予測において有益となる可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Imaging scoring systems for preoperative molecular diagnoses of lower-grade gliomas.2018

    • Author(s)
      Tokunori Kanazawa, Hirokazu Fujiwara, Hidenori Takahashi, Yuya Nishiyama, Yuichi Hirose, Saeko Tanaka(Ichimura), Kazunari YoshidaHikaru Sasaki
    • Journal Title

      Neurosurgical Review

      Volume: - Issue: 2 Pages: 433-441

    • DOI

      10.1007/s10143-018-0981-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Molecular-genetic and clinicopathological prognostic factors in patients with gliomas showing total 1p19q loss: Gain of chromosome 19p and histological grade III negatively correlate with patient's prognosis2017

    • Author(s)
      Hayashi S, Kitamura Y, Hirose Y, Yoshida K, Sasaki H
    • Journal Title

      Journal of Neuro-Oncology

      Volume: 132(1) Issue: 1 Pages: 119-126

    • DOI

      10.1007/s11060-016-2344-1

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Molecular investigation of brain tumors progressing during pregnancy orpostpartum period2017

    • Author(s)
      Saeko Tanaka(Saeko Hayashi), Hikaru Sasaki, Kentaro Ohara, Maya Kono, Katsuhiro Mizutani, Yohei Kitamura, Ryuichi Kanai, Takenori Akiyama, Masahiro Toda, Michihiro Kono, Kazunari Yoshida
    • Organizer
      The 14th meeting of the Asian Society for Neuro-Oncology (ASNO)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Molecular investigation of brain tumors progressing during pregnancy or postpartum period2016

    • Author(s)
      Saeko Tanaka(Saeko Hayashi), Hikaru Sasaki, Kentaro Ohara, Maya Kono, Katsuhiro Mizutani, Yohei Kitamura, Ryuichi Kanai, Takenori Akiyama, Masahiro Toda, Kazunari Yoshida
    • Organizer
      Society of Neuro-Oncology (SNO)
    • Place of Presentation
      Scottsdale, Arizona, USA
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Molecular investigation of brain tumors progressing during perinatal period2016

    • Author(s)
      Saeko Hayashi, Hikaru Sasaki, Kentaro Ohara, Maya Kono, Katsuhiro Mizutani, Yohei Kitamura, Ryuichi Kanai, Takenori Akiyama, Masahiro Toda, Michihiro Kono, Kazunari Yoshida
    • Organizer
      分子脳神経外科学会
    • Place of Presentation
      帝京大学板橋キャンパス(東京都板橋区)
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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