Differentiating between Central Nervous System Lymphoma and High-grade Glioma Using Dynamic Susceptibility Contrast and Dynamic Contrast-enhanced MR Imaging with Histogram Analysis

• Project/Area Number: 16K20028
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: Fujita Health University
• Principal Investigator: Murayama Kazuhiro 藤田保健衛生大学, 医学部, 講師 (40622931)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: MR灌流画像 / 悪性神経膠腫 / 中枢神経悪性リンパ腫 / 神経膠腫 / 脳神経疾患

Outline of Final Research Achievements

We evaluated the diagnostic performance of histogram analysis of data from a combination of dynamic susceptibility contrast (DSC)-magnetic resonance imaging (MRI) and dynamic contrast-enhanced (DCE)-MRI for quantitative differentiation between central nervous system lymphoma (CNSL) and high-grade glioma (HGG), with the aim of identifying useful perfusion parameters as objective radiological markers for differentiating between them.
The combination of Ktrans by DCE-MRI and cCBV by DSC-MRI was found to reveal the characteristics of vascularity and permeability of a lesion more precisely than either Ktrans or cCBV alone. Histogram analysis of these vascular microenvironments enabled quantitative differentiation between CNSL and HGG.

Research Products

• [Journal Article] Differentiating between Central Nervous System Lymphoma and High-grade Glioma Using Dynamic Susceptibility Contrast and Dynamic Contrast-enhanced MR Imaging with Histogram Analysis (2018)
  • Author(s): Murayama K, Nishiyama Y, Hirose Y, Abe M, Ohyu S, Ninomiya A, Fukuba T, Katada K, Toyama H.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 17 Issue: 1 Pages: 42-49
  • DOI: 10.2463/mrms.mp.2016-0113
  • NAID: 130006306808
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Differentiating between Central Nervous System Lymphoma and High-grade Glioma Using Dynamic Susceptibility Contrast and Dynamic Contrast-enhanced MR Imaging with Histogram Analysis (2017)
  • Author(s): Kazuhiro Murayama
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 印刷中
  • NAID: 130006306808
  • Peer Reviewed / Open Access
• [Presentation] Histogram Analysis of Intravoxel Incoherent Motion in Peritumoral Edema for Distinguishing between Central Nervous System Lymphoma and Other Brain Tumors (2017)
  • Author(s): Kazuhiro Murayama, Takashi Fukuba, Shigeharu Ohyu, Ayako Ninomiya, Kazuhiro Katada, Hiroshi Toyama
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Int'l Joint Research
• [Presentation] Histogram Analysis of Intravoxel Incoherent Motion to Assess High T2-weighted Signal Intensity around Brain Tumor: Initial Clinical Experience (2017)
  • Author(s): Kazuhiro Murayama, Shigeharu Ohyu, Ayako Ninomiya, Takashi Fukuba, Kazuhiro Katada, Hiroshi Toyama
  • Organizer: 日本医学放射線学会
• [Presentation] Differentiation of central nervous system lymphoma and gliomas using dynamic susceptibility contrast and dynamic contrast-enhanced MRI with half dose contrast media (2016)
  • Author(s): Kazuhiro Murayama
  • Organizer: International Society for Magnetic Resonance in Medicine
  • Place of Presentation: Suntec Singapore Convention & Exhibition Centre
  • Year and Date: 2016-05-07
  • Int'l Joint Research
• [Presentation] Diagnostic performance of dynamic contrast-enhanced MRI in differentiating central nervous system lymphoma from other tumors (2016)
  • Author(s): Kazuhiro Murayama
  • Organizer: 日本医学放射線学会総会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2016-04-14