Development of treatment for radiation-induced brain injury using HMGB1 antibody
| Project/Area Number |
16K20032
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurosurgery
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| Research Institution | Osaka University (2017-2018)
Research Institute, Osaka Medical Center for Cancer and Cardiovascular Disaeses (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 放射線脳障害 / HMGB1 / WBRT |
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| Outline of Final Research Achievements |
The purpose of this study is whether the extracellular release of HMGB1 is occur due to radiation-induced brain injury. In this study, extracellular release of HMGB1 was occur in the microglia of the brain after irradiation. Additionally, the phenomenon occurs at different sites by the time after irradiation. This result has the possibility of treatment for radiation-induced brain injury using HMGB1 antibodies.
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| Academic Significance and Societal Importance of the Research Achievements |
転移性脳腫瘍患者の生命予後は延長している。転移性脳腫瘍に対する治療法として放射線の全脳照射が一般的に行われているが、その副作用として遅発性の放射線脳障害が代表的であり、治療後の生活に影響を与えるため大きな問題となっている。本研究ではマウスを用いた実験を行い、放射線照射後の脳内でHMGB1の核外放出が認められることを明らかにした。その結果から、抗HMGB1抗体を用いた放射線障害に対する新たなる治療の可能性を見出すことができたと考えている。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Downregulation of EGFR in a metastatic brain lesion of EGFR-mutated non-small cell lung cancer using a tyrosine kinase inhibitor: A case report.2017
Author(s)
Takagaki M, Kinoshita M, Nishino K, Nakano M, Adachi H, Ueno M, Kitamura M, Fujimoto Y, Tashiro K, Tomita Y, Imamura F, Yoshimine T.
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Journal Title
Oncol. Lett.
Volume: 13
Issue: 4
Pages: 2085-2088
DOI
Related Report
Peer Reviewed / Open Access
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