| Project/Area Number |
16K20036
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HIRAI Takashi 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (40510350)
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| Co-Investigator(Renkei-kenkyūsha) |
OKAWA Atsushi 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30251507)
ENOMOTO Mitsuhiro 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (90451971)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 神経障害性疼痛 / 脊髄障害 / 末梢神経 / 後根神経節 / RNAシーケンス / 脊髄損傷 / 次世代シーケンス / 末梢神経障害 / 標的遺伝子 / 軸索輸送 |
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| Outline of Final Research Achievements |
RNA-seq analysis revealed that expression patterns were not consistent in 30 candidate genes of spinal cord injury model rats between individuals. In both peripheral nerve injury and spinal cord injury, extended variants were apparently observed in the 3’UTR sequence of several genes, including TRPV1, TRPA1, Fam134b and Naa15.These results suggest that structure of ‘pain matrix’ might change in dorsal root ganglia located caudally to the epicenter of the spinal cord which results in the onset and maintenance of chronic pain.
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