| Project/Area Number |
16K20045
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Research Collaborator |
Okamoto Masanori
Sasaki Jun
Mukuno Midori
Saito Naoto
Kato Hiroyuki
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 抗PD-1抗体 / 骨肉腫 / PD-1 / モデルマウス / Wntシグナル |
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| Outline of Final Research Achievements |
We examined whether anti-PD-1 antibody, an effective new drug against melanoma etc., is effective against osteosarcoma. We used a model in which osteosarcoma was implanted subcutaneously in the back of the mouse to compared treated with anti-PD-1 antibody group with control group. We observed the survival time and the tumor volume. As a result, administration of anti-PD-1 antibody prolonged the survival days , and it was possible to suppress an increase in tumor volume. In addition, it was newly found that the administration of anti-PD-1 antibody reduces suppressive T cells that suppress the immune response to the tumor.
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