Up-regulation of CaVb1 expression in denervation-induced muscle atrophy
| Project/Area Number |
16K20046
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Orthopaedic surgery
|
|---|
| Research Institution | Shinshu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | Ｌ型カルシウムチャネル / サルコペニア / L型カルシウムチャネル / 除神経 / 筋委縮 |
|---|
| Outline of Final Research Achievements |
We previously found that an expression level of CaVβ1 in the tibialis anterior (TA) was significantly increased by sciatic nerve transection. In this study, we revealed that the variant of CaVβ with increased expression was likely as CaVβ1a. Quantitative PCR showed that a CaVβ1 mRNA level was not increased but significantly decreased by sciatic nerve transection, suggesting that increases in CaVβ1 protein was due to post-translational modification. Overexpression of CaVβ1a by adeno-associated virus vector in the tibialis anterior muscles of wild type mice did not significantly change the contractile forces. Further studies are necessary to reveal a role of CaVβ1 in the pathophysiology of muscle atrophy.
|
Report
(3 results)
Research Products
(1 results)
