| Project/Area Number |
16K20065
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
Inoue Hiroaki 京都府立医科大学, 医学(系)研究科(研究院), 助教 (60457968)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 移植腱 / 組織学的検討 / 前十字靱帯再建術 / 移植腱再構築 / PRP / β‐TCP / β-TCP |
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| Outline of Final Research Achievements |
The influence of PRP on the healing process was examined histologically using a model in which the Achilles tendon is implanted in the rat femur. Achilles tendon and graft bone as a control group, β-TCP group added with β-TCP, and β-TCP + PRP group added with PRP were compared. Two weeks after surgery, the inflammatory cell infiltration was the mildest in the β-TCP + PRP group, and generally fine tendon fibers could be confirmed. Fine tendon fibers were confirmed in all groups at 4 weeks after surgery, but in the control group and the β-TCP group, dense interstitial tissue was found between the transplanted tendon and bone.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果、PRPはβ‐TCPを用いた靱帯再建術において、炎症を最小限にしながら移植腱－骨癒合を促進する可能性がある。
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