| Project/Area Number |
16K20077
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Asahikawa Medical College |
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Principal Investigator |
KANDA Megumi 旭川医科大学, 医学部, 助教 (50516820)
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| Research Collaborator |
KANDA Hirotsugu 旭川医科大学, 医学部, 講師 (00550641)
IIDA Takafumi 旭川医科大学, 医学部, 助教 (40468442)
HAO Shuanglin University of Miami, Preclinical and Basic Research Department of Anesthesiology, Professor and Director
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 遺伝子治療 / ウイルスベクター / 神経障害性疼痛 / 妊娠による鎮痛効果 / 難治性疼痛 / アンチセンス法 / 活性酸素 / ミトコンドリア |
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| Outline of Final Research Achievements |
While effective antiretroviral treatment makes human immunodeficiency virus (HIV)-related death decreased dramatically, neuropathic pain becomes one of the most common complications in patients with HIV/acquired immunodeficiency syndrome (AIDS). The exact mechanisms of HIV-related neuropathic pain are not well understood yet, and no effective therapy is for HIV-pain. Evidence has shown that proinflammatory factors (e.g., tumor necrosis factor alpha (TNFα)) released from glia, are critical to contributing to chronic pain. Preclinical studies have demonstrated that non-replicating herpes simplex virus (HSV)-based vector expressing human enkephalin reduces inflammatory pain, neuropathic pain, or cancer pain in animal models. In this study, we describe recent advances in the use of HSV-based gene transfer for the treatment of HIV pain, with a special focus on the use of HSV-mediated soluble TNF receptor I (neutralizing TNFα in function) in HIV neuropathic pain model.
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