Contribution of glycinnergic neurons to spinal plasticity in neuropathic pain

Research Project

Project/Area Number	16K20083
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Anesthesiology
Research Institution	Niigata University
Principal Investigator	KUEABE MIYUKI 新潟大学, 医歯学総合病院, 助教 (30635579)
Project Period (FY)	2016-04-01 – 2018-03-31
Project Status	Completed (Fiscal Year 2017)
Budget Amount *help	¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000) Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	脊髄 / 痛み / in vivoパッチクランプ / 神経障害性痛 / in vivo パッチクランプ / 脊髄後角 / グリシントランスポーター / in vivoパッチクランプ法
Outline of Final Research Achievements	Little is known about the role of glycineergic neuron of spinal dorsal horn in neuropathic pain. We analyzed changes of inhibitory neuronal transmission between normal rats and neuropathic pain model rats using in vivo patch-clamp technique. As a result, only the amplitude of the inhibitory postsynaptic current decreased. There was no difference in the frequency and amplitude of glycineergic IPSC between the two groups. Furthermore, in model rats relative GABAergic neurons increased. The balance changes of these inhibitory neurons were thought to play a part of plasticity change in neuropathic pain.

Report

(3 results)