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Contribution of glycinnergic neurons to spinal plasticity in neuropathic pain

Research Project

Project/Area Number 16K20083
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionNiigata University

Principal Investigator

KUEABE MIYUKI  新潟大学, 医歯学総合病院, 助教 (30635579)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脊髄 / 痛み / in vivoパッチクランプ / 神経障害性痛 / in vivo パッチクランプ / 脊髄後角 / グリシントランスポーター / in vivoパッチクランプ法
Outline of Final Research Achievements

Little is known about the role of glycineergic neuron of spinal dorsal horn in neuropathic pain. We analyzed changes of inhibitory neuronal transmission between normal rats and neuropathic pain model rats using in vivo patch-clamp technique. As a result, only the amplitude of the inhibitory postsynaptic current decreased. There was no difference in the frequency and amplitude of glycineergic IPSC between the two groups. Furthermore, in model rats relative GABAergic neurons increased. The balance changes of these inhibitory neurons were thought to play a part of plasticity change in neuropathic pain.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report

Research Products

(4 results)

All 2017 2016

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Intravenous administration of lidocaine directly acts on spinal dorsal horn and produces analgesic effect: An in vivo patch-clamp analysis.2016

    • Author(s)
      Kurabe M, Furue H, Kohno T
    • Journal Title

      Scientific Reports

      Volume: 6 Pages: 0-0

    • DOI

      10.1038/srep26253

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perforation of the superior vena cava 5 days after insertion of a central venous catheter through the left internal jugular vein2016

    • Author(s)
      Miyuki Kurabe, Tatsunori Watanabe, Tatsuro Kohno
    • Journal Title

      Journal of Clinical Anesthesia

      Volume: 31 Pages: 193-196

    • DOI

      10.1016/j.jclinane.2016.02.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Effects of desflurane versus propofol on cerebral oxygenation by near-infrared spectroscopy during robotic assisted laparoscopic radical prostatectomy2017

    • Author(s)
      Miyuki Kurabe
    • Organizer
      Anesthesiology 2017, Boston
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plasticity and circuitry of spinal pathways after peripheral nerve injury: An in vivo patch-clamp recording2016

    • Author(s)
      Miyuki Kurabe
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego(アメリカ合衆国)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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