| Project/Area Number |
16K20097
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 酸素 / 周術期 / 人工呼吸 / 全身麻酔 / 術後呼吸器合併症 / 酸素療法 / 麻酔 / 呼吸管理 / 術後合併症 / 集中治療 / 多施設 / 観察研究 / 分離肺換気 / 臨床 / 酸化ストレス |
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| Outline of Final Research Achievements |
Despite the potentially harmful effects of oxygen overexposure, supplemental oxygen therapy is commonly prescribed in several clinical conditions. However, little is known about current oxygen administration practices during general anesthesia. We conducted a multicenter, cross-sectional study to assess current ventilator management, especially oxygen management, during general anesthesia in 1498 patients at 43 hospitals in Japan. We found potential hyperoxemia and substantial oxygen exposure were common during general anesthesia, especially in patients receiving one-lung ventilation. Our findings support the need for future clinical trials to evaluate the safety and feasibility of conservative approaches for oxygen use during general anesthesia.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、いまだ明らかになっていなかった全身麻酔中の酸素療法の現状を報告した。その結果、全身麻酔中は高酸素血症が高率で発生しており、酸素投与を制限する余地が十分に存在することが分かり、酸素の使用を制限する介入研究を行うことの妥当性を示すことができた。次に計画している介入研究で、酸素の使用を厳重に管理する制限的酸素療法の安全性、有効性が証明できれば、医療費の削減や患者予後の改善につながる可能性がある。
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