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Mechanisms of antinociceptive effect on spinal level of beta-endolphin by using voltage imaging system

Research Project

Project/Area Number 16K20113
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Anesthesiology
Research InstitutionDokkyo Medical University

Principal Investigator

TERASHIMA TETSUJI  獨協医科大学, 医学部, 助教 (30526398)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsβエンドルフィン / オピオイド受容体 / 脊髄後角 / サブスタンスP / NK1受容体拮抗薬 / 坐骨神経結紮モデル / Brain Vision / 膜電位イメージング / NK1受容体 / CP99994 / 膜電位感受性色素 / 内因性オピオイド / 鎮痛 / サブスタンスP
Outline of Final Research Achievements

We have reported that one of the antinociceptive mechanisms of beta-endorphin acted without releasing of substance P from primary afferent. In order to further elucidate such mechanisms, we assessed the optical synaptic transmission for neuropathic mice by using brain vison system.
Electrical stimulation of dorsal root ganglion showed that fluorescent change of voltage-sensitive dye in dorsal horn in a sequential manner, and the ratio of the release of substance P rised compared with control group.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (1 results)

  • [Journal Article] 鉄剤投与で改善した慢性疼痛の1例2017

    • Author(s)
      木村 嘉之, 寺島 哲二, 小澤 継史, 濱口 眞輔, 山口 重樹
    • Journal Title

      慢性疼痛

      Volume: 36 Pages: 137-138

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed
  • [Journal Article] フェンタニル貼付剤の乱用が自殺企図の誘因となった慢性痛の一症例2016

    • Author(s)
      秦要人、寺島哲二、小松崎誠、山口重樹、濱口眞輔
    • Journal Title

      慢性疼痛

      Volume: 35 Pages: 57-60

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] 慢性痛患者に対する柴胡剤の使用経験2016

    • Author(s)
      濱口眞輔、小澤継史、沼田祐貴、寺島哲二、木村嘉之、北島敏光
    • Journal Title

      痛みと漢方

      Volume: 26 Pages: 170-174

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 海外医療ボランティアのすすめ~獨協医科大学病院の試み~2018

    • Author(s)
      寺島哲二
    • Organizer
      第18回日本麻酔科学ウインターセミナー
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 一次求心性線維の電気刺激による脊髄後角表層のサブスタンスPを介した脱分極の同定2017

    • Author(s)
      金子堅太郎、五月女俊也、沼田祐貴、寺島哲二、山口重樹、堀雄一
    • Organizer
      第94回日本生理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Slow changes in neuronal excitability in the spinal superficial dorsal horn evoked by the activation of unmyelinated primary afferents2017

    • Author(s)
      Kaneko K, Saotome T, Numata Y, Terashima T, Yamaguchi S, Hori Y
    • Organizer
      47th annual meeting of the Society for Neuroscience, Washington DC
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] TIVAハンズオンセミナー2017

    • Author(s)
      寺島哲二
    • Organizer
      第24回日本静脈麻酔学会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 不適切なオピオイド治療が原因と考えられた振り込め詐欺被害2017

    • Author(s)
      寺島哲二、山口重樹、濱口眞輔、高薄敏史、木村嘉之、篠崎未緒
    • Organizer
      第46回日本慢性疼痛学会
    • Place of Presentation
      京都三大学教養教育共同化施設「稲森記念会館」 (京都府京都市)
    • Related Report
      2016 Research-status Report
  • [Book] 薬局2018

    • Author(s)
      山口重樹、寺島哲二
    • Total Pages
      152
    • Publisher
      南山堂
    • Related Report
      2017 Annual Research Report

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Published: 2016-04-21   Modified: 2019-03-29  

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