To develop a new therapeutic method targeting AKR1C1 for urothelial carcinoma micrometastasis

• Project/Area Number: 16K20122
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Hokkaido University
• Principal Investigator: Matsumoto Ryuji 北海道大学, 医学研究院, 助教 (10762536)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: 尿路上皮癌 / 転移 / 薬剤耐性 / AKR1C1 / 微小転移 / 泌尿器科学 / 腫瘍学

Outline of Final Research Achievements

The effect of increasing bladder cancer cell cisplatin sensitivity and suppressing cell invasion capacity was observed in fenamic acid type nonsteroidal anti - inflammatory drugs such as flufenamic acid and mefenamic acid which have AKR1C1 inhibitory effect. In the study using clinical specimens, AKR1C1 was significantly increased in urothelial carcinoma metastatic site compared with primary site, and the effect of suppressing metastasis by the AKR1C1 inhibitor and enhancing the anticancer drug therapeutic effect on the metastatic lesion was expected. Currently, it is under observation that cisplatin and fenamic acid are administered to mice, and the application amount of fenamic acid is being studied.

Research Products

• [Journal Article] Perioperative morbidity and mortality of octogenarians treated by radical cystectomy-a multi-institutional retrospective study in Japan. (2017)
  • Author(s): Abe T, Takada N, Kikuchi H, Matsumoto R, Osawa T, Murai S, Miyajima N,
  • Journal Title: Jpn J Clin Oncol. Volume: 47 Issue: 8 Pages: 755-761
  • DOI: 10.1093/jjco/hyx062
  • NAID: 120006352214
  • Peer Reviewed / Open Access
• [Journal Article] Aldo-keto reductase 1C1 induced by interleukin-1beta mediates the invasive potential and drug resistance of metastatic bladder cancer cells. (2016)
  • Author(s): Matsumoto R, Tsuda M, Yoshida K, Tanino M, Kimura T, Nishihara H, Abe T, Shinohara N, Nonomura K, Tanaka S
  • Journal Title: Scientific reports Volume: 4 Issue: 1 Pages: 34625-34625
  • DOI: 10.1038/srep34625
  • Peer Reviewed / Open Access
• [Journal Article] Role of surgical consolidation in metastatic urothelial carcinoma. (2016)
  • Author(s): Abe T, Matsumoto R, Shinohara N
  • Journal Title: Curr Opin Urol. Volume: 26 Issue: 6 Pages: 573-580
  • DOI: 10.1097/mou.0000000000000329
  • Peer Reviewed / Open Access
• [Journal Article] Outcome of metastatic urothelial carcinoma treated by systemic chemotherapy: Prognostic factors based on real-world clinical practice in Japan. (2016)
  • Author(s): Abe T, Ishizaki J, Kikuchi H, Minami K, Matsumoto R, Harabayashi T, Sazawa A, Mochizuki T, Chiba S, Akino T, Murakumo M, Miyajima N, Tsuchiya K, Maruyama S, Murai S, Shinohara N.
  • Journal Title: Urologic oncology Volume: 35 Issue: 2 Pages: 38.e1-38.e8
  • DOI: 10.1016/j.urolonc.2016.08.016
  • Peer Reviewed / Open Access
• [Presentation] 当院での腎部分切除術におけるTrifecta達成についての検討 (2017)
  • Author(s): 松本隆児、間山郁美、小山敏樹、柏木明、熊谷章
  • Organizer: 日本泌尿器科学会総会
• [Presentation] 転移性尿路上皮癌二次化学療法における予後因子の検討 (2017)
  • Author(s): 松本隆児、安部崇重、石崎淳司、菊地央、原林透、三浪圭太、佐澤陽、望月端吾、千葉智市、秋野文臣、村雲雅志、宮田遥、大澤崇宏、丸山覚、村井祥代、篠原信雄
  • Organizer: 第55回日本癌治療学会学術集会
• [Presentation] 上部尿路癌に対する腹腔鏡下腎尿管全摘除術＋所属リンパ節郭清の治療成績 (2017)
  • Author(s): 松本隆児、安部崇重、高田徳容、三浪圭太、原林透、菊地央、大澤崇宏、丸山覚、篠原信雄
  • Organizer: 第31回日本泌尿器内視鏡学会総会
• [Presentation] ロボット支援前立腺全摘除術後PSA再発に関する検討 (2016)
  • Author(s): 松本隆児、間山郁美、小山敏樹、柏木明、熊谷章
  • Organizer: 第30回日本泌尿器内視鏡学会総会
  • Place of Presentation: ナレッジキャピタルコングレコンベンションセンター（大阪府大阪市）
  • Year and Date: 2016-11-17
• [Presentation] 膀胱全摘術における拡大リンパ節郭清の意義 (2016)
  • Author(s): 松本隆児、安部崇重、高田徳容、三浪圭太、原林透、永森聡、宮島直人、土屋邦彦、丸山覚、篠原信雄
  • Organizer: 第104回日本泌尿器科学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-04-23
• [Presentation] 進行性尿路上皮癌の治療戦略 Oligometastasisに対する転移巣切除術 (2016)
  • Author(s): 松本隆児、安部祟重、石崎淳司、大澤崇宏、菊地央、丸山覚、土屋邦彦、宮島直人、篠原信雄
  • Organizer: 第104回日本泌尿器科学会総会
  • Place of Presentation: 仙台国際センター（宮城県仙台市）
  • Year and Date: 2016-04-23