| Project/Area Number |
16K20125
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Chiba University |
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Principal Investigator |
KATO MAYUKO 千葉大学, 医学部附属病院, 助教 (80733857)
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| Co-Investigator(Renkei-kenkyūsha) |
ICHIKAWA TOMOHIKO 千葉大学, 大学院医学研究院, 教授 (20241953)
SEKI NAOHIKO 千葉大学, 大学院医学研究院, 准教授 (50345013)
KOJIMA SATOKO 帝京大学, 医学部, 准教授 (10345019)
OKATO ATSUSHI 千葉大学, 医学部附属病院, 医員 (90756719)
ARAI TAKAYUKI 千葉大学, 医学部附属病院, 医員 (40793055)
KOSHIZUKA KEIICHI 千葉大学, 医学部附属病院, 医員 (00791609)
YAMADA YASUTAKA 千葉大学, 医学部附属病院, 医員 (30814595)
SUGAWARA SYO 千葉大学, 医学部附属病院, 医員 (70815290)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | マイクロRNA / 前立腺癌 / 細胞外マトリックス / 去勢抵抗性前立腺癌 / 癌抑制遺伝子 / 癌遺伝子 |
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| Outline of Final Research Achievements |
microRNA(miRNA) expression profile in castration-resistant prostate cancer(CRPC) revealed that miR-205-5p was reduced in CRPC tissues and that it acted as an antitumor miRNA. We focused on HMGB3 as a putative target of miR-205-5p regulation. HMGB3 was directly regulated by miR-205-5p in PCa cells and HMGB3 was overexpressed in CRPC clinical specimens.
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