Basic study for development of overactive bladder treatment targeting 5-HT3 receptor-positive cells.
| Project/Area Number |
16K20135
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 5-HT3受容体 / 過活動膀胱 / 膀胱機能障害 |
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| Outline of Final Research Achievements |
In this study, I investigated the role of the 5-HT3 receptor in bladder function. First, I revealed that 5-HT3 receptors were expressed in the course of micturition reflex abundantly. In this process, I found 5-HT3 receptor-positive cells in bladder muscular layer. These cells were regarded as ganglionic neurons of parasympathetic nerves. These results suggested that the 5-HT3 receptor has significant roles for the bladder function. Next, I performed functional analysis. I revealed that 5-HT3 receptor agonist decreased mouse bladder volume. Therefore, the 5-HT3 receptor was suggested to be associated with the pathological condition of the overactive bladder.
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Report
(3 results)
Research Products
(3 results)
