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Screening for new genes for resistance to drug in prostate cancer

Research Project

Project/Area Number 16K20136
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionOsaka University

Principal Investigator

Kawamura Norihiko  大阪大学, 医学系研究科, 招へい教員 (40722658)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords癌 / 薬剤耐性メカニズム / スクリーニング / 前立腺癌 / 薬剤耐性 / 薬剤感受性関連遺伝子
Outline of Final Research Achievements

The aim of this research is to identify new genes associated with resistance to docetaxel in prostate cancer, to clarify the mechanisms. Using CRISPR/Cas9 knockout screening system, we extacted several candidate genes. We examined whether these candidate genes knockout increase docetaxel-sensitivity in prostate cancer cell line, but knockout of these genes showed no difference of sensitivity to docetaxel, comparing to control cells.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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