Screening for new genes for resistance to drug in prostate cancer

• Project/Area Number: 16K20136
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Osaka University
• Principal Investigator: Kawamura Norihiko 大阪大学, 医学系研究科, 招へい教員 (40722658)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 癌 / 薬剤耐性メカニズム / スクリーニング / 前立腺癌 / 薬剤耐性 / 薬剤感受性関連遺伝子

Outline of Final Research Achievements

The aim of this research is to identify new genes associated with resistance to docetaxel in prostate cancer, to clarify the mechanisms. Using CRISPR/Cas9 knockout screening system, we extacted several candidate genes. We examined whether these candidate genes knockout increase docetaxel-sensitivity in prostate cancer cell line, but knockout of these genes showed no difference of sensitivity to docetaxel, comparing to control cells.