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The mechanism of immune cells associated with prostate cancer progression

Research Project

Project/Area Number 16K20137
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionOsaka University

Principal Investigator

Hayashi Takuji  大阪大学, 医学部附属病院, 医員 (50747079)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords前立腺癌 / 免疫細胞 / 高脂肪食 / 炎症 / HVJ-E / 抗PD-1抗体 / モデルマウス / 癌
Outline of Final Research Achievements

Administration of HVJ-E and anti-PD1 antibody didn't suppress prostate cancer progression of model mice.
HFD accelerated tumor growth and pro-tumor changes of local immune cells, both of which were suppressed by celecoxib. HFD-induced tumor growth was associated with IL6 signaling.
Preipheral blood monocyte count, reflecting tumor-infiltrating macrophages, is a predictive factor for adverse pathology and postoperative biochemical failure of prostate cancer patients.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2018 2017 2016

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (8 results)

  • [Journal Article] Peripheral blood monocyte count reflecting tumor-infiltrating macrophages is a predictive factor of adverse pathology in radical prostatectomy specimens.2017

    • Author(s)
      Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Norihiko Kawamura, Kentaro Jingushi, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Ryoichi Imamura, Eiichi Morii, Norio Nonomura
    • Journal Title

      The Prostate

      Volume: 77 Pages: 1383-1388

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum monocyte fraction of white blood cells is increased in patients with high Gleason score prostate cancer.2016

    • Author(s)
      Takuji Hayashi, Kazutoshi Fujita, Go Tanigawa, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Tetsuya Takao, Seiji Yamaguchi, Norio Nonomura
    • Journal Title

      Oncotarget

      Volume: -

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] 高脂肪食は局所のIL6シグナルを介した炎症反応によって前立腺癌の進展を促進する2018

    • Author(s)
      林 拓自、藤田和利、野島 聡、林裕次郎、中野剛佑、石津谷祐、王 総、山本致之、木内利郎、松崎恭介、神宮司健太郎、加藤大悟、河嶋厚成、氏家 剛、永原 啓、植村元秀、森井英一、辻川和丈、野々村祝夫
    • Organizer
      第27回泌尿器科分子・細胞研究会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高脂肪食摂取は前立腺癌の進展を促進し、局所の免疫細胞を変化させる2017

    • Author(s)
      林 拓自、藤田和利、石津谷 祐、王 総、山本致之、木内利郎、松崎恭介、川村憲彦、河嶋厚成、氏家 剛、永原 啓、植村元秀、野々村祝夫
    • Organizer
      第26回泌尿器科分子・細胞研究会
    • Place of Presentation
      大分
    • Year and Date
      2017-03-10
    • Related Report
      2016 Research-status Report
  • [Presentation] 前立腺癌モデルマウスにおいて、高脂肪食は癌の進展と前立腺組織内免疫細胞の腫瘍促進性変化を起こす2017

    • Author(s)
      林 拓自、藤田和利、石津谷 祐、王 聡、山本致之、木内利郎、松崎恭介、川村憲彦、河嶋厚成、氏家 剛、永原 啓、植村元秀、野島 聡、森井英一、野々村祝夫
    • Organizer
      第105回日本泌尿器科学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] High fat diet-induced inflammation accelerates tumor progression in mice model for prostate cancer2017

    • Author(s)
      Takuji Hayashi, Kazutoshi Fujita, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Norihiko Kawamura, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Motohide Uemura, Satoshi Nojima, Eiichi Morii, Norio Nonomura
    • Organizer
      AUA 2017 Annual Meeting
    • Related Report
      2017 Annual Research Report
  • [Presentation] 前立腺癌モデルマウスにおいて高脂肪食による腫瘍進展は免疫反応と関連する2017

    • Author(s)
      林 拓自、藤田和利、野島 聡、木内利郎、松崎恭介、神宮司健太郎、河嶋厚成、氏家 剛、永原 啓、植村元秀、辻川和丈、森井英一、野々村祝夫
    • Organizer
      第76回日本癌学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 高グリソンスコアの前立腺癌患者の末梢血中単球分画は上昇している2017

    • Author(s)
      林 拓自、藤田和利、谷川 剛、山本致之、木内利郎、松崎恭介、川村憲彦、河嶋厚成、氏家 剛、永原 啓、植村元秀、高尾徹也、山口誓司、野々村祝夫
    • Organizer
      第55回日本癌治療学会総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 遺伝子改変前立腺癌モデルマウスにおける局所での免疫細胞の検討2016

    • Author(s)
      林 拓自、藤田和利、石津谷 祐、王 総、山本致之、木内利郎、松崎恭介、川村憲彦、河嶋厚成、氏家 剛、永原 啓、植村元秀、野々村祝夫
    • Organizer
      第75回日本癌学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 遺伝子改変前立腺癌発症モデルマウスの樹立とその自然史2016

    • Author(s)
      林 拓自、藤田和利、山本致之、木内利郎、松崎恭介、川村憲彦、中田 渡、吉田栄宏、河嶋厚成、氏家 剛、永原 啓、植村元秀、野々村祝夫
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2016-04-23
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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