The mechanism of immune cells associated with prostate cancer progression
Project/Area Number |
16K20137
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Osaka University |
Principal Investigator |
Hayashi Takuji 大阪大学, 医学部附属病院, 医員 (50747079)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 前立腺癌 / 免疫細胞 / 高脂肪食 / 炎症 / HVJ-E / 抗PD-1抗体 / モデルマウス / 癌 |
Outline of Final Research Achievements |
Administration of HVJ-E and anti-PD1 antibody didn't suppress prostate cancer progression of model mice. HFD accelerated tumor growth and pro-tumor changes of local immune cells, both of which were suppressed by celecoxib. HFD-induced tumor growth was associated with IL6 signaling. Preipheral blood monocyte count, reflecting tumor-infiltrating macrophages, is a predictive factor for adverse pathology and postoperative biochemical failure of prostate cancer patients.
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Report
(3 results)
Research Products
(10 results)
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[Journal Article] Peripheral blood monocyte count reflecting tumor-infiltrating macrophages is a predictive factor of adverse pathology in radical prostatectomy specimens.2017
Author(s)
Takuji Hayashi, Kazutoshi Fujita, Satoshi Nojima, Yujiro Hayashi, Kosuke Nakano, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Norihiko Kawamura, Kentaro Jingushi, Atsunari Kawashima, Akira Nagahara, Takeshi Ujike, Motohide Uemura, Ryoichi Imamura, Eiichi Morii, Norio Nonomura
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Journal Title
The Prostate
Volume: 77
Pages: 1383-1388
Related Report
Peer Reviewed / Open Access
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[Presentation] High fat diet-induced inflammation accelerates tumor progression in mice model for prostate cancer2017
Author(s)
Takuji Hayashi, Kazutoshi Fujita, Yu Ishizuya, Cong Wang, Yoshiyuki Yamamoto, Toshiro Kinouchi, Kyosuke Matsuzaki, Norihiko Kawamura, Atsunari Kawashima, Takeshi Ujike, Akira Nagahara, Motohide Uemura, Satoshi Nojima, Eiichi Morii, Norio Nonomura
Organizer
AUA 2017 Annual Meeting
Related Report
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