| Project/Area Number |
16K20150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Project Status |
Completed (Fiscal Year 2017)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 慢性膀胱虚血 / 動脈硬化 / 虚血再灌流障害 / 下部尿路機能障害 / 過活動膀胱 / 医療・福祉 / シグナル伝達 |
|---|
| Outline of Final Research Achievements |
Epidemiological studies have shown that lower urinary tract symptoms (LUTS), such as nocturia, urinary incontinence and urgency, are common among both men and women, with age-related increases seen in both sexes. The pathophysiology of LUTS, particularly in the elderly, is multifactorial. Pelvic arterial occlusive disease, including atherosclerosis, has recently been suggested to cause chronic bladder ischemia, which may play an key role in the development of LUTS in men and women. This study suggested that chronic ischemia affceted folic acid metabolic pathway and apical membrane of urinary bladder. It is possible that changed folic acid metabolic pathway and apical membrane of urinary bladder is one cause of chronic ischemia related lower urinary tract dysfunction.
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