Immunosupressive sgent for prostate cancer

• Project/Area Number: 16K20152
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Urology
• Research Institution: Yokohama City University
• Principal Investigator: Kawahara Takashi 横浜市立大学, 附属市民総合医療センター, 診療講師 (40555570)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 前立腺癌 / 膀胱癌 / 免疫抑制座 / NFATc1 / CRPC / 腫瘍学

Outline of Final Research Achievements

Our study revealed that higher NFATc1 played an iportant role in prostate cancer progression. Immunosupressive agents supressed NFATc1 activity and reulted in supression of prostate cancer progression.

Academic Significance and Societal Importance of the Research Achievements

本研究では現在では治療困難なホルモン抵抗性前立腺癌に対するまったく新し機序の抗腫瘍効果を認める薬剤を確認した。現在、すでに移植領域で使用されている薬剤なので、今後臨床応用がすぐに可能である。

Research Products

• [Journal Article] Gastrointestinal cancer and bilateral hydronephrosis resulted in a high risk of ureteral stent failure (2018)
  • Author(s): Ohtaka Mari、Kawahara Takashi、Takamoto Daiji、Mochizuki Taku、Hattori Yusuke、Teranishi Jun-ichi、Makiyama Kazuhide、Miyoshi Yasuhide、Yumura Yasushi、Yao Masahiro、Uemura Hiroji
  • Journal Title: BMC Urology Volume: 18 Issue: 1
  • DOI: 10.1186/s12894-018-0346-3
  • Peer Reviewed / Open Access
• [Journal Article] The analysis of human papillomavirus DNA in penile cancer tissue by in???situ hybridization (2018)
  • Author(s): Takamoto Daiji、Kawahara Takashi、Kasuga Jun、Sasaki Takeshi、Yao Masahiro、Yumura Yasushi、Uemura Hiroji
  • Journal Title: Oncology Letters Volume: -
  • DOI: 10.3892/ol.2018.8351
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of an automated bone scan index for men with metastatic castration-resistant prostate cancer treated with cabazitaxel (2018)
  • Author(s): Uemura Koichi、Miyoshi Yasuhide、Kawahara Takashi、Ryosuke Jikuya、Yamashita Daisuke、Yoneyama Shuko、Yokomizo Yumiko、Kobayashi Kazuki、Kishida Takeshi、Yao Masahiro、Uemura Hiroji
  • Journal Title: BMC Cancer Volume: 18 Issue: 1
  • DOI: 10.1186/s12885-018-4401-y
  • Peer Reviewed / Open Access
• [Journal Article] Fluorescent Light-Guided Cystoscopy with 5-ALA Aids in Accurate Surgical Margin Detection for TURBO: A Case Report (2018)
  • Author(s): Takamoto Daiji、Kawahara Takashi、Ohtake Shinji、Mochizuki Taku、Kuroda Shinnosuke、Nakaigawa Noboru、Izumi Koji、Miyoshi Yasuhide、Makiyama Kazuhide、Yao Masahiro、Sawazumi Tomoe、Inayama Yoshiaki、Ohta Junichi、Uemura Hiroji
  • Journal Title: Case Reports in Oncology Volume: 11 Issue: 1 Pages: 164-167
  • DOI: 10.1159/000487390
  • Peer Reviewed / Open Access
• [Journal Article] NFATc1 Expression as a Prognosticator in Urothelial Carcinoma of the Upper Urinary Tract (2017)
  • Author(s): Kawahara T, Inoue S, Fujita, Mizushima T, Ide H, Yamaguchi S, Fushimi H, Nonomura N, Miyamoto H
  • Journal Title: Transl Oncol. Volume: 10 Issue: 3 Pages: 318-318
  • DOI: 10.1016/j.tranon.2017.01.012
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] A low psoas muscle volume predicts longer hospitalization and cancer recurrence in upper urinary tract urothelial carcinoma (2017)
  • Author(s): Tsutsumi Sohgo、Kawahara Takashi、Teranishi Jun?Ichi、Yao Masahiro、Uemura Hiroji
  • Journal Title: Molecular and Clinical Oncology Volume: -
  • DOI: 10.3892/mco.2017.1537
  • Peer Reviewed / Open Access
• [Journal Article] RANK/RANKL expression in prostate cancer. (2017)
  • Author(s): Ohtaka M, Kawahara T, Mochizuki T, Takamoto D, Hattori Y, Teranishi JI, Miyoshi Y, Yumura Y, Hasumi H, Yokomizo Y, Hayashi N, Kondo K, Yao M, Miyamoto H, Uemura H.
  • Journal Title: Int J Surg Case Rep. Volume: 30 Pages: 106-106
  • DOI: 10.1016/j.ijscr.2016.11.042
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Developing a preoperative predictive model for ureteral length for ureteral stent insertion. (2016)
  • Author(s): Kawahara T, Sakamaki K, Ito H, Kuroda S, Terao H, Makiyama K, Uemura H, Yao M, Miyamoto H, Matsuzaki J.
  • Journal Title: BMC Urol. Volume: 16 Pages: 70-70
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Efficacy of Immediate Switching from Bicalutamide to Flutamide as Second-Line Combined Androgen Blockade. (2016)
  • Author(s): .Yokomizo Y, Kawahara T, Miyoshi Y, Otani M, Yamanaka S, Teranishi J, Noguchi K, Yao M, Uemura H.
  • Journal Title: Biomed Res Int. Volume: なし Pages: 1-7
  • DOI: 10.1155/2016/4083183
  • Peer Reviewed / Open Access