Elucidation of epigenome-mediated proliferation mechanism in bladder cancer and development of therapy with novel inhibitors
Project/Area Number |
16K20154
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Urology
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Research Institution | Nagoya City University |
Principal Investigator |
Iida Keitaro 名古屋市立大学, 大学院医学研究科, 臨床研究医 (30713945)
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Research Collaborator |
Yasui Takahiro 名古屋市立大学, 大学院医学研究科, 教授 (40326153)
Suzuki Takayoshi 京都府立医科大学, 大学院医学研究科, 教授 (90372838)
Kawai Noriyasu 名古屋市立大学, 大学院医学研究科, 准教授 (20254279)
Ando Ryosuke 名古屋市立大学, 大学院医学研究科, 講師 (30381867)
Naiki Taku 名古屋市立大学, 大学院医学研究科, 助教 (50551272)
Etani Toshiki 名古屋市立大学, 大学院医学研究科, 助教 (30600754)
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Project Period (FY) |
2016-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | エピジェネティクス / ヒストン修飾 / LSD1 / 膀胱癌 / オートファジー / エピゲノム / アポトーシス / 膀胱癌臨床検体 / ヒストン脱メチル化 / 薬剤耐性 / NCL1 |
Outline of Final Research Achievements |
We investigated therapeutic potential of a novel histone lysine demethylase 1 (LSD1) inhibitor, NCL1, in bladder cancer. Bladder cancer cell lines were treated with NCL1, and LSD1 and cell viability were assessed. Bladder cancer cells showed strong LSD1 expression, and cell viability was decreased by NCL1. In addition, autophagy was induced by NCL1 treatment. Autophagy inhibitor, chloroquine, demonstrated synergic anti-tumor effect with NCL1. In TCGA database, LSD1 RNA expression in bladder cancer was significant higher than that in normal bladder tissues. We suggest that NCL1 and autophagy inhibitor is a potential therapeutic agent for bladder cancer.
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Report
(3 results)
Research Products
(14 results)
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[Journal Article] Early abiraterone acetate treatment is beneficial in Japanese castration-resistant prostate cancer after failure of primary combined androgen blockade.2018
Author(s)
Nagai T, Naiki T (corresponding), Iida K, Etani T, Ando R, Hamamoto S, Sugiyama Y, Akita H, Kubota H, Hashimoto Y, Kawai N, Yasui T.
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Journal Title
Prostate Int
Volume: 1
Issue: 1
Pages: 18-23
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] A pilot study of gemcitabine and paclitaxel as third-line chemotherapy in metastatic urothelial carcinoma2017
Author(s)
Naiki T, Iida K, Kawai N, Etani T, Ando R, Nagai T, Tanaka Y, Hamamoto S, Hamakawa T, Akita H, Sugiyama Y, Yasui T.
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Journal Title
Journal of Rural Medicine
Volume: 12
Issue: 2
Pages: 105-111
DOI
NAID
ISSN
1880-487X, 1880-4888
Related Report
Peer Reviewed / Open Access
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[Journal Article] Bacillus Calmette-Guerin therapy after the second transurethral resection significantly decreases recurrence in patients with new onset high-grade T1 bladder cancer.2016
Author(s)
Iida Keitaro, Naiki Taku, Kawai Noriyasu, Etani Toshiki, Ando Ryosuke, Ikegami Yosuke, Okamura Takehiko, Kubota Hiroki, Okada Atsushi, Kohri Kenjiro, Yasui Takahiro
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Journal Title
BMC Urology
Volume: 16
Issue: 1
Pages: 8-8
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Nonpalpable testicular pure seminoma with elevated serum alpha-fetoprotein presenting with retroperitoneal metastasis: a case report.2016
Author(s)
Iwatsuki Shoichiro, Naiki Taku, Kawai Noriyasu, Etani Toshiki, Iida Keitaro, Ando Ryosuke, Nagai Takashi, Okada Atsushi, Tozawa Keiichi, Sugiyama Yosuke, Yasui Takahiro
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Journal Title
Journal of Medical Case Reports
Volume: 10
Issue: 1
Pages: 114-114
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Inflammatory myofibroblastic tumor of the urinary bladder: a case report.2016
Author(s)
Etani Toshiki, Naiki Taku, Nagai Takashi, Iida Keitaro, Ando Ryosuke, Naiki-Ito Aya, Kawai Noriyasu, Tozawa Keiichi, Mizuno Kentaro, Okada Atsushi, Mogami Tohru, Yasui Takahiro
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Journal Title
Case Reports in Oncology
Volume: 17
Issue: 2
Pages: 464-469
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Safety of regional 8-MHz radiofrequency capacitive hyperthermia combined with magnetic cationic liposomes in patients with castration-resistant prostate cancer: a phase Ⅰ clinical study.2016
Author(s)
Kawai Noriyasu, Kobayashi Takeshi, Kobayashi Daichi, Tsutsumiuchi Kaname, Iida Keitaro, Etani Toshiki, Naiki Taku, Ando Ryosuke, Mizuno Kentaro, Okada Atsushi, Tozawa Keiichi, Yasui Takahiro
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Journal Title
Journal of International Translational Medicine
Volume: 4
Pages: 258-267
Related Report
Peer Reviewed / Open Access
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[Presentation] Effectiveness of lysine specific demethylase 1 inhibitor for castration resistant prostate cancer.2017
Author(s)
Etani Toshiki, Naiki Taku, Nagai Takashi, Iida Keitaro, Ando Ryosuke, Kawai Noriyasu, Tozawa Keiichi, Mogami Tohru, Kohri Kenjiro, Suzuki Takayoshi, Yasui Takahiro
Organizer
第105回日本泌尿器科学会総会
Related Report
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