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Elucidation of epigenome-mediated cell population movement control mechanism in kidney cancer lung metastasis

Research Project

Project/Area Number 16K20158
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionOsaka City University

Principal Investigator

FUJIOKA Masaki  大阪市立大学, 大学院医学研究科, 特任講師 (10648463)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords転移性腎癌 / 肺転移 / エピジェネティクス / 動物実験モデル / miRNA / protrusion形成 / collective cell movement
Outline of Final Research Achievements

Establishment of therapeutic strategies aimed at cure of metastatic renal cancer and elucidation of the metastatic mechanism are one of the common hot topics held by domestic and overseas urology departments. As a concept of the current metastatic mechanism, metastasis via cell mass movement and protrusion formation is known. Enhancement of cell mass movement and protrusion formation has been found in renal carcinoma high metastatic cell lines established by applicants so far. As a result of knockout of high metastatic strain specific miRNA in the previous study, suppression of protrusion formation was observed in the high metastatic strain. However, when the same miRNA was forcibly expressed in the low metastatic parent strain, the formation of protoplasts was not observed, but the cell group formation ability increased.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (24 results)

All 2018 2017 2016 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results,  Open Access: 8 results,  Acknowledgement Compliant: 2 results) Presentation (14 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis2017

    • Author(s)
      Kakehashi Anna、Ishii Naomi、Okuno Takahiro、Fujioka Masaki、Gi Min、Wanibuchi Hideki
    • Journal Title

      Int J Mol Sci

      Volume: 18 Issue: 8 Pages: 1801-1801

    • DOI

      10.3390/ijms18081801

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital2017

    • Author(s)
      Kakehashi Anna、Ishii Naomi、Okuno Takahiro、Fujioka Masaki、Gi Min、Fukushima Shoji、Wanibuchi Hideki
    • Journal Title

      Oxid Med Cell Longev

      Volume: 2017 Issue: 1 Pages: 1-16

    • DOI

      10.1155/2017/8541064

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chemopreventive Action by Ethanol-extracted Brazilian Green Propolis on Post-initiation Phase of Inflammation-associated Rat Colon Tumorigenesis.2017

    • Author(s)
      Doi K, Fujioka M, Sokuza Y, Ohnishi M, Gi M, Takeshita M, Kumada K, Kakehashi A, Wanibuchi H.
    • Journal Title

      In Vivo.

      Volume: 31 Issue: 2 Pages: 187-197

    • DOI

      10.21873/invivo.11044

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diphenylarsinic acid exerts promotion effects on hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay2017

    • Author(s)
      Ishii N, Gi M, Fujioka M, Yamano S, Okumura M, Kakehashi A, Wanibuchi H.
    • Journal Title

      Journal of Toxicologic Pathology

      Volume: 30 Issue: 1 Pages: 39-45

    • DOI

      10.1293/tox.2016-0049

    • NAID

      130005297205

    • ISSN
      0914-9198, 1881-915X
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Carbonic anhydrase 2 is a novel invasion-associated factor in urinary bladder cancers.2017

    • Author(s)
      Tachibana H, Gi M, Kato M, Yamano S, Fujioka M, Kakehashi A, Hirayama Y, Koyama Y, Tamada S, Nakatani T, Wanibuchi H.
    • Journal Title

      Cancer Sci

      Volume: 108 Issue: 3 Pages: 331-337

    • DOI

      10.1111/cas.13143

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A chronic toxicity study of diphenylarsinic acid in F344 rats in drinking water for 52 weeks.2017

    • Author(s)
      Yamaguchi T, Gi M, Yamano S, Fujioka M, Tatsumi K, Kawachi S, Ishii N, Doi K, Kakehashi A, Wanibuchi H.
    • Journal Title

      Exp Toxicol Pathol

      Volume: 69 Issue: 1 Pages: 1-7

    • DOI

      10.1016/j.etp.2016.10.002

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats.2016

    • Author(s)
      Fujioka M, Gi M, Kawachi S, Tatsumi K, Ishii N, Doi K, Kakehashi A, Wanibuchi H
    • Journal Title

      J Environ Sci

      Volume: 49 Pages: 125-130

    • DOI

      10.1016/j.jes.2016.07.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ethanol-Extracted Brazilian Propolis Exerts Protective Effects on Tumorigenesis in Wistar Hannover Rats.2016

    • Author(s)
      Kakehashi A, Ishii N, Fujioka M, Doi K, Gi M, Wanibuchi H
    • Journal Title

      PLoS One

      Volume: 11 Issue: 7 Pages: e0158654-e0158654

    • DOI

      10.1371/journal.pone.0158654

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Detection of non-genotoxic hepatocarcinogens and prediction of their mechanism of action in rats using gene marker sets2016

    • Author(s)
      Kanki M, Gi M, Fujioka M, Wanibuchi H.
    • Journal Title

      The Journal of Toxicological Sciences

      Volume: 41 Issue: 2 Pages: 281-292

    • DOI

      10.2131/jts.41.281

    • NAID

      130005132661

    • ISSN
      0388-1350, 1880-3989
    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] マウス経胎盤ばく露による有機ヒ素化合物Dimethylarsinic acidの発がん性およびその機序2018

    • Author(s)
      藤岡正喜、魏民、奥野高裕、熊田賢次、梯アンナ、大石裕司、鰐渕英機
    • Organizer
      第34回日本毒性病理学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット肝発がん物質ダンマル樹脂による非遺伝毒性肝発がん機序の検討2017

    • Author(s)
      藤岡正喜、魏民、河内聡子、奥野高裕、梯アンナ、鰐渕英機
    • Organizer
      2017先端モデル動物支援プラットフォーム
    • Place of Presentation
      琵琶湖ホテル(滋賀県大津市)
    • Year and Date
      2017-02-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 1,2-ジクロロプロパンおよびジクロロメタン複合曝露によるマウス肝臓への影響2017

    • Author(s)
      藤岡正喜、魏民、河内聡子、梯アンナ、鰐渕英機
    • Organizer
      第16回分子予防環境医学研究会
    • Place of Presentation
      熊本国際交流会館(熊本県熊本市)
    • Year and Date
      2017-02-03
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス経胎盤ばく露による有機ヒ素化合物DMAの発がん性およびその機序2017

    • Author(s)
      藤岡正喜
    • Organizer
      先端モデル動物支援プラットフォーム若手講習会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Carcinogenicity induced by prenatal exposure to dimethylarsinic acid in CD1 mice2017

    • Author(s)
      藤岡正喜、魏民、熊田賢次、奥野高裕、梯アンナ、鰐渕英機
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 1,2-ジクロロプロパンおよびジクロロメタン複合曝露によるマウス肝臓への影響2017

    • Author(s)
      藤岡正喜、魏民、河内聡子、梯アンナ、鰐渕英機
    • Organizer
      第44回日本毒性学会学術年会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 非アルコール性脂肪肝炎モデルマウスを用いた肝細胞癌の発がんメカニズム解析2017

    • Author(s)
      藤岡正喜、奥野高裕、石井真美、梯アンナ、魏民、鰐渕英機
    • Organizer
      第14回日本病理学会カンファレンス
    • Related Report
      2017 Annual Research Report
  • [Presentation] マウス経胎盤ばく露による有機ヒ素化合物Dimethylarsinic acidの発がん性およびその機序2017

    • Author(s)
      藤岡正喜、魏民、奥野高裕、熊田賢次、梯アンナ、大石裕司、鰐渕英機
    • Organizer
      第23回ヒ素シンポジウム
    • Related Report
      2017 Annual Research Report
  • [Presentation] ラット経尿道直接膀胱暴露法を用いた有機ヒ素化合物DMMTAのin vivo変異原性の検討2017

    • Author(s)
      藤岡正喜、魏民、河内聡子、辰己久美子、梯アンナ、鰐渕英機
    • Organizer
      第33回日本毒性病理学会総会および学術集会
    • Place of Presentation
      ビッグ・アイ国際障害者交流センター(大阪府堺市)
    • Related Report
      2016 Research-status Report
  • [Presentation] F344 gpt deltaラット膀胱粘膜および肝臓におけるiAsIIIおよびDMAVのin vivo変異原性の検討2016

    • Author(s)
      藤岡正喜、魏民、河内聡子、熊田賢次、鰐渕英機
    • Organizer
      第22回ヒ素シンポジウム
    • Place of Presentation
      産業技術総合研究所(東京都江東区)
    • Year and Date
      2016-11-17
    • Related Report
      2016 Research-status Report
  • [Presentation] Evaluation of in vivo mutagenicity of iAsIII and DMAV in gpt delta F344 rat2016

    • Author(s)
      Fujioka M, Gi M, Kawachi S, Tatsumi K, Kumada K, Wanibuchi H
    • Organizer
      IUTOX XIV International Congress of Toxicology Merida-Mexico
    • Place of Presentation
      メリダ(メキシコ合衆国)
    • Year and Date
      2016-10-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] NADPH oxidase阻害剤Apocyninは酸化ストレスの抑制を介しEHEN誘発ラット腎発がんを抑制する2016

    • Author(s)
      藤岡 正喜, 魏 民, 山野 荘太郎, 河内 聡子, 土井 賢一郎, 石井 真美, 梯 アンナ, 鰐渕 英機
    • Organizer
      第69回日本酸化ストレス学会学術集会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2016-08-30
    • Related Report
      2016 Research-status Report
  • [Presentation] ラット腎癌肺高転移株を用いた転移亢進に寄与する分子生物学的特性の検討2016

    • Author(s)
      藤岡正喜、山野荘太郎、魏民、河内聡子、辰己久美子、熊田賢次、鰐渕英機
    • Organizer
      第13回日本病理学会カンファレンス
    • Place of Presentation
      六甲山ホテル(兵庫県神戸市)
    • Year and Date
      2016-07-29
    • Related Report
      2016 Research-status Report
  • [Presentation] 非遺伝毒性ラット肝発がん物質ダンマル樹脂の発がん機序の検討2016

    • Author(s)
      藤岡正喜、魏民、河内聡子、辰已久美子、熊田賢次、鰐渕英機
    • Organizer
      がん予防学術大会2016
    • Place of Presentation
      名古屋大学(愛知県名古屋市)
    • Year and Date
      2016-07-01
    • Related Report
      2016 Research-status Report
  • [Remarks] 大阪市立大学大学院医学研究科分子病理学

    • URL

      http://www.med.osaka-cu.ac.jp/pathology/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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