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New therapeutic strategy for treatment of CRPC targeting cell cycle regulation.

Research Project

Project/Area Number 16K20161
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Urology
Research InstitutionKeio University

Principal Investigator

Ezaki Taisuke  慶應義塾大学, 医学部(信濃町), 助教 (50598422)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords前立腺癌 / 去勢抵抗性前立腺癌 / CDK4 / CDK4阻害剤 / 去勢抵抗性前立腺癌(CRPC) / アンドロゲン・アンドロゲンレセプター軸
Outline of Final Research Achievements

Although androgen / androgen receptor axis plays a key role in progression of castration-resistant prostate cancer (CRPC), mutation or alteration involving other signaling pathways are also enriched in CRPC. We focused on CDK4, cell cycle regulator, and investigated the therapeutic effect of CDK4 inhibitor, using the human prostate cancer cell line, the human CRPC cell line, and the docetaxel-resistant CRPC cell line. It was found that anti-cancer effect of CDK4 inhibitor was exhibited regardless of the sensitivity to hormone or docetaxel of the cell lines. We also showed that AR expression was not affected by CDK4 inhibitor. These results implied that alteration of cell cycle control plays some important role in CRPC progression and CDK4 inhibitor might be effective in the treatment of CRPC.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2016

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Journal Article] Should We Try Antiandrogen Withdrawal in Castration-Resistant Prostate Cancer Patients? Insights From a Retrospective Study.2016

    • Author(s)
      Hongo H, Kosaka T, Mizuno R, Ezaki T, Matsumoto K, Morita S, Shinoda K, Shinojima T, Kikuchi E, Miyajima A, Oya M.
    • Journal Title

      Clinical Genitourinary Cancer

      Volume: Epub ahead of print Issue: 6 Pages: e569-e573

    • DOI

      10.1016/j.clgc.2016.02.014

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 転移性前立腺癌に対するホルモン療法における、初期の治療反応性と予後の関連について2016

    • Author(s)
      江崎太佑
    • Journal Title

      泌尿器外科

      Volume: 29(8) Pages: 1325-1326

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2019-03-29  

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