Research Project
Grant-in-Aid for Young Scientists (B)
We retrospectively analyzed the clinical records of 206 patients with localized prostate cancer (Pca) performed radical prostatectomy and immunohistochemically analyzed the expression of VASH2. The expression of VASH2 was observed to vascular endothelial cells (ECs) of microvessels in the tumor stroma and Pca cells. We immunohistochemically examined the tumor cells with VASH2 as VASH2 score (proportion score x intensity score of tumor staining) and the microvessels with activated ECs as VASH2 density. Then, we analyzed the association between immunohistochemical expression and clinical outcomes.VASH2 score was significantly associated with Gleason score and pathological T stage (p<0.05). The 5-year PSA recurrence-free survival rates were significantly worse in high VASH2 score (P< 0.05). Multivariate analyses revealed that high VASH2 score was an independent prognostic indicator of PSA recurrence (P= 0.006).
All 2018 2017 2016
All Presentation (4 results) (of which Int'l Joint Research: 2 results)