Establishment of novel treatment for ovarian cancer via histone methylation control
| Project/Area Number |
16K20171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | GSKJ4 / Histone / methylation / JMJD3 / ヒストン / メチル化 / 卵巣癌 / がん幹細胞 / 卵巣がん / 抗癌剤 / シスプラチン / タキソール / 医学 / 婦人科癌 |
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| Outline of Final Research Achievements |
We reported that GSKJ4 induces cell death in ovarian cancer stem cells and causes cancer stem cell properties to be lost.Subsequent studies with collaborators have found that GSKJ4 induces cell death in non-small cell lung cancer cell lines. This suggested that the effect of GSKJ4 is not specific to cancer stem cells but also to cancer cells.Furthermore, it was found that by combining GSKJ4 and cisplatin, taxol, metformin, the effect on cancer cells is added.In addition, as a mechanism of action of GSKJ4, it was shown that cell cycle was induced by influencing the cell cycle and inducing apoptosis.
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Aripiprazole, an Antipsychotic and Partial Dopamine Agonist, Inhibits Cancer Stem Cells and Reverses Chemoresistance.2016
Author(s)
Suzuki S, Okada M, Kuramoto K, Takeda H, Sakaki H, Watarai H, Sanomachi T, Seino S, Yoshioka T, Kitanaka C.
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Journal Title
Anticancer Res.
Volume: 36(10)
Pages: 5153-5161
Related Report
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