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Estrogen-mediated regulation of energy balance via adipocyte beiging

Research Project

Project/Area Number 16K20174
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionThe University of Tokyo

Principal Investigator

Ueda Kazutaka  東京大学, 医学部附属病院, 特任助教 (60375798)

Co-Investigator(Renkei-kenkyūsha) TAKIMOTO Eiki  東京大学, 医学部附属病院, 講師 (20709513)
Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsエストロゲン / 中枢神経系 / 肥満 / 女性ホルモン / 褐色脂肪 / 糖尿病 / 中枢神経 / シグナル伝達 / 性ステロイドホルモン
Outline of Final Research Achievements

A novel knock-in mouse line with the selective blockade of the membrane-initiated estrogen receptor (ER) pathway was employed, and we found that the lack of this pathway precipitated excessive weight gain and glucose intolerance independent of food intake, and that this was accompanied by impaired adaptive thermogenesis and reduced physical activity. Notably, the central activation of protein phosphatase (PP) 2A improved metabolic disorders induced by the lack of membrane-initiated ER signaling. Furthermore, the anti-obesity effect of estrogen replacement in a murine menopause model was abolished by central PP2A inactivation. These findings define a critical role for membrane-initiated ER signaling in metabolic homeostasis via the central action of PP2A.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2017 2016 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results)

  • [Int'l Joint Research] Tufts Medical Center(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Unliganded estrogen receptor alpha regulates vascular cell function and gene expression2017

    • Author(s)
      Lu Qing、Schnitzler Gavin R.、Vallaster Caroline S.、Ueda Kazutaka、Erdkamp Stephanie、Briggs Christine E.、Iyer Lakshmanan K.、Jaffe Iris Z.、Karas Richard H.
    • Journal Title

      Mol Cell Endocrinol

      Volume: 442 Pages: 12-23

    • DOI

      10.1016/j.mce.2016.11.019

    • Related Report
      2017 Annual Research Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] ER Alpha Rapid Signaling Is Required for Estrogen Induced Proliferation and Migration of Vascular Endothelial Cells2016

    • Author(s)
      Lu Q, Schnitzler GR, Ueda K, Iyer LK, Diomede OI, Andrade T, Karas RH.
    • Journal Title

      PLOS ONE

      Volume: 11 Issue: 4 Pages: e0152807-e0152807

    • DOI

      10.1371/journal.pone.0152807

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] エストロゲン受容体 Rapid, non-genomic シグナル経路による代謝恒常性の制御2016

    • Author(s)
      上田和孝、瀧本英樹、Richard H. Karas、小室一成
    • Organizer
      日本心血管内分泌代謝学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report
  • [Presentation] エストロゲン受容体 Rapid, non-genomic シグナル経路による代謝恒常性の制御2016

    • Author(s)
      上田和孝、瀧本英樹、Richard H. Karas、小室一成
    • Organizer
      日本臨床分子医学会学術集会 学術奨励(YIA)セッション
    • Place of Presentation
      東京
    • Year and Date
      2016-04-15
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-16  

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