Analysis of miRNAs regulated by transcription factor C/EBPb in decidualization

• Project/Area Number: 16K20194
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Yamaguchi University
• Principal Investigator: JOZAKI Kosuke 山口大学, 大学院医学系研究科, 助教 (80721323)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脱落膜化 / miRNA / 転写因子 / マイクロRNA / 子宮内膜 / 発現制御 / ゲノム / 発生・分化

Outline of Final Research Achievements

This study aimed to identify novel miRNA regulated by transcriptional factor C/EBPb in human endometrial stromal cells (ESCs) during decidualization using RNA sequencing. As a result, hsa-miR-29c and has-miR-1182 were extracted. Two miRNAs may play important roles in expression of many genes during decidualization.