| Project/Area Number |
16K20198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagasaki University |
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Principal Investigator |
FUCHI Naoki 長崎大学, 医歯薬学総合研究科(医学系), 研究協力員 (20727359)
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| Research Collaborator |
MIURA Kiyonori
MASUZAKI Hideaki
SASAKI Daisuke
HASEGAWA Hiroo
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HTLV-1 / キャリア / 妊娠 / プロウイルス量 / 制御性T細胞 / sIL-2R / sIL-2受容体 / 母子感染 / 妊婦 / 産婦人科 / 産科学 / 母子感染症 |
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| Outline of Final Research Achievements |
The influence of pregnancy on human T-cell leukemia virus type 1 (HTLV-1) infection and proviral DNA levels among pregnant women with HTLV-1 has not been clarified. We prospectively gathered blood samples from 36 pregnant women in whom HTLV-1 carriage was previously diagnosed and sequentially measured their proviral DNA levels. The HTLV-1 proviral DNA levels remained at a plateau during pregnancy but were elevated after delivery. Moreover, flow cytometry and serological analyses revealed that the regulatory T-cell population and soluble interleukin 2 receptor levels were similarly elevated after birth in comparison with those in control pregnant women. These findings will guide the establishment of a better program to prevent mother-to-child transmission of HTLV-1.
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