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The effects of steroid hormones on atherosclerosis risk

Research Project

Project/Area Number 16K20201
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Ito Fumitake  京都府立医科大学, 医学(系)研究科(研究院), 助教 (60756849)

Project Period (FY) 2016-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsホルモン補充療法 / 動脈硬化 / 接着因子 / プロゲストーゲン / ドロスピレノン / ジエノゲスト / ステロイドホルモン / 女性医学
Outline of Final Research Achievements

In this study, the effects of the alternative progestogen drospirenone (DRSP) on monocyte adhesion in human umbilical venous endothelial cells (HUVECs) were examined. In HUVECs treated with estrogens and progestogens, including DRSP and medroxyprogesterone acetate (MPA), the expression of the adhesion molecules were examined. A flow chamber system was used to investigate the effects of DRSP on monocytoid cell adherence to HUVEC monolayers. Upregulation of adhesion molecule mRNA or protein was not seen in HUVECs treated with DRSP alone or with 17β-estradiol + DRSP. DRSP alone, 17β-estradiol + DRSP or ethinylestradiol + DRSP did not increase the number of adherent monocytoid cells to HUVECs in the flow chamber system. These results suggest that DRSP may be an alternative to MPA in hormone replacement therapy.

Report

(3 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • Research Products

    (11 results)

All 2017 2016

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (5 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Increased ipsilateral uterine artery vascular resistance in women with ovarian endometrioma2017

    • Author(s)
      Waratani Miyoko、Mori Taisuke、Ito Fumitake、Tanaka Yukiko、Koshiba Akemi、Takahata Akiko、Kitawaki Jo
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 43 Issue: 4 Pages: 736-743

    • DOI

      10.1111/jog.13266

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction2017

    • Author(s)
      Tanaka Yukiko、Mori Taisuke、Ito Fumitake、Koshiba Akemi、Takaoka Osamu、Kataoka Hisashi、Maeda Eiko、Okimura Hiroyuki、Mori Takahide、Kitawaki Jo
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism

      Volume: 102 Issue: 9 Pages: 3206-3217

    • DOI

      10.1210/jc.2017-00052

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enlarged uterine corpus volume in women with endometriosis: Assessment using three-dimensional reconstruction of pelvic magnetic resonance images.2016

    • Author(s)
      Koshiba A, Mori T, Ito F, Tanaka Y, Takaoka O, Takahata A, Kitawaki J.
    • Journal Title

      J Obstet Gynaecol Res

      Volume: 43 Issue: 1 Pages: 157-163

    • DOI

      10.1111/jog.13153

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of low-dose combined drospirenone-ethinylestradiol on perimenstrual symptoms experienced by women with endometriosis2016

    • Author(s)
      Tanaka Y, Mori T, Ito F, Koshiba A, Kusuki I, Kitawaki J
    • Journal Title

      Int J Gynaecol Obstet

      Volume: 135 Issue: 2 Pages: 135-139

    • DOI

      10.1016/j.ijgo.2016.05.004

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-tumor effect of estrogen-related receptor alpha knockdown on uterine endometrial cancer.2016

    • Author(s)
      Matsushima H, Mori T, Ito F, Yamamoto T, Akiyama M, Kokabu T, Yoriki K, Umemura S, Akashi K, Kitawaki J.
    • Journal Title

      Oncotarget.

      Volume: 3 Issue: 23 Pages: 3-3

    • DOI

      10.18632/oncotarget.9151

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Effects of drospirenone on adhesion molecule expression and monocyte adherence in human endothelial cells.2016

    • Author(s)
      Ito F, Mori T, Takaoka O, Tanaka Y, Koshiba A, Tatsumi H, Iwasa K, Kitawaki J.
    • Journal Title

      Eur J Obstet Gynecol Reprod Biol

      Volume: 201 Pages: 113-117

    • DOI

      10.1016/j.ejogrb.2016.03.044

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Equilin in conjugated equine estrogen increases monocyte-endothelial adhesion via NF-κB signaling2017

    • Author(s)
      Fumitake Ito, Taisuke Mori, Osamu Takaoka, Yukiko Tanaka, Akemi Koshiba, Hiroshi Tatsumi, Jo Kitawaki
    • Organizer
      Asia & Oceanic Congress of Obstetrics and Gynecology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Drospirenoneによる血管内皮接着分子発現への影響2017

    • Author(s)
      伊藤文武、小芝明美、辰巳 弘、北脇 城
    • Organizer
      日本女性医学学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] CEEに含まれるequilinはERβ発現低下を介して動脈硬化リスクとなる2017

    • Author(s)
      伊藤文武、森 泰輔、辰巳 弘、北脇 城
    • Organizer
      日本内分泌学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 各種プロゲスチンの 血管内皮への単球接着に及ぼす影響2017

    • Author(s)
      伊藤文武
    • Organizer
      第6回プロゲスチン研究会
    • Place of Presentation
      東京
    • Related Report
      2016 Research-status Report
  • [Presentation] CEEに含まれるequilinはNF-κB活性化経路を介して動脈硬化リスクとなる2016

    • Author(s)
      伊藤文武
    • Organizer
      第31回日本女性医学学会
    • Place of Presentation
      京都
    • Year and Date
      2016-11-05
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2019-03-29  

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