| Project/Area Number |
16K20205
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
|
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| Research Collaborator |
BANNO Kouji
TOMINAGA Eiichiro
KUNITOMI Haruko
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2017: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 卵巣癌 / 創薬 / ドラッグリポジショニング / メバロン酸合成経路 / ワールブルグ効果回避 / 酸化的リン酸化シフト / メバロン酸合成経路阻害剤 / ビスフォスフォネート / L-778123 / 婦人科腫瘍 |
|---|
| Outline of Final Research Achievements |
Statins exerts the antitumor effect by not only inhibiting the mevalonate synthesis pathway including the farnesyl transferase and geranylgeranyl transferase but also showing pleiotropic effect on other action pathways. Furthermore, in the statin mediated ovarian cancer cell line, metabolites related to the TCA circuit such as phenylalanine, methionine, tryptophan, valine, acetyl coenzyme A were increased, whereas the final product of the anaerobic glycolytic pathway lactic acid was reduced. It is suggested that the statin administration interferes the Warburg effect and activates the TCA cycle and shifts it to oxidative phosphorylation in mitochondria.
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