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Establishment of a novel mouse xenograft model of human uterine leiomyoma and development of non hormonal therapy using decorin

Research Project

Project/Area Number 16K20219
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Obstetrics and gynecology
Research InstitutionOsaka Medical College

Principal Investigator

Suzuki Yusuke  大阪医科大学, 医学部, 非常勤医師 (90770925)

Research Collaborator Ii Masaaki  
Terai Yoshito  
Ohmichi Masahide  
Asahi Michio  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords子宮筋腫 / 子宮筋腫移植モデル / 子宮筋腫モデルマウス / Gn-RH / エストロゲン / プロゲステロン / 子宮内膜症 / leiomyoma / ヒト子宮筋腫マウスモデル / 筋腫 / マウス皮下移植モデル / マウスモデル / GnRHアゴニスト / 皮下移植モデル / デコリン
Outline of Final Research Achievements

Uterine leiomyoma is the most common benign tumour in women, and an appropriate animal model for leiomyoma would be useful for exploring new therapeutic strategies. Therefore, we have been challenged to develop a new simple mouse model for human leiomyoma. As a result, this model will be useful for the development of new therapeutic strategies.

Academic Significance and Societal Importance of the Research Achievements

本研究により、作製が容易で移植後も発育する新しいヒト子宮筋腫マウスモデルを確立した。このマウスモデルは、子宮筋腫に対する新しい治療法の開発に役立つと考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2018

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results)

  • [Journal Article] Establishment of a novel mouse xenograft model of human uterine leiomyoma2018

    • Author(s)
      Yusuke Suzuki
    • Journal Title

      Scientific Reports

      Volume: 8(1) Issue: 1 Pages: 8872-8872

    • DOI

      10.1038/s41598-018-27138-1

    • NAID

      120006545188

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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