Development of novel vestibular rehabilitation relating interaction between eye movement system and vestibular system

• Project/Area Number: 16K20222
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Hokkaido University
• Principal Investigator: Fujiwara Keishi 北海道大学, 医学研究院, 講師 (70600146)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 平衡リハビリテーション / 末梢前庭障害 / 前庭動眼反射 / 滑動性眼球運動 / video Head Impulse Test / 平衡科学

Outline of Final Research Achievements

The objective of this research is to develop novel vestibular rehabilitation relating interaction between eye movement system and vestibular system. Video Head Impulse Test (vHIT) has been used to evaluate the function of semicircular canal. Although vertical canal function could not be evaluated by conventional tests, dysfunction of the semicircular canals, including the vertical canals, in patients with vestibular schwannoma (VS) was detected by vHIT. The anterior semicircular canal was less frequently involved than the horizontal or posterior semicircular canal. And significant negative correlations were observed between the semicircular canal function and hearing level in patients with VS.

Academic Significance and Societal Importance of the Research Achievements

末梢前庭障害による難治性の平衡障害に対しては、薬物治療の有効性に乏しく、平衡リハビリテーションによる治療効果が期待される。回転による前庭刺激と、滑動性眼球運動刺激を組み合わせた新しい平衡リハビリテーションを開発することによって、従来のリハビリテーションと比べてより高い有効性が得られる可能性がある。平衡障害は患者の生活の質を著しく下げるものであり、それに対する新規治療法の開発は、平衡障害に悩む患者にとって大きな福音となるものである。

Research Products

• [Journal Article] Evaluation of vertical semicircular canal function in patients with vestibular schwannoma (2019)
  • Author(s): Fujiwara K, Yanagi H, Morita S, Hoshino K, Fukuda A, Nakamaru Y, Homma A
  • Journal Title: Ann Otol Rhinol Laryngol Volume: 128 Issue: 2 Pages: 113-120
  • DOI: 10.1177/0003489418808545
  • Peer Reviewed
• [Journal Article] Factors affecting the effect of physical rehabilitation therapy for synkinesis as a sequela to facial nerve palsy (2018)
  • Author(s): Fujiwara K, Furuta Y, Yamamoto N, Katoh K, Fukuda S
  • Journal Title: Auris Nasus Larynx Volume: 45 Issue: 4 Pages: 732-739
  • DOI: 10.1016/j.anl.2017.10.003
  • Peer Reviewed
• [Journal Article] 両側半規管麻痺を呈した大動脈炎症候群の1例 (2018)
  • Author(s): 藤原圭志、本間明宏
  • Journal Title: Equilibrium Research Volume: 77 Pages: 64-68
  • NAID: 130007382874
  • Peer Reviewed
• [Journal Article] 顔面神経麻痺患者に対するメーキャップ治療の精神面に対する効果 (2018)
  • Author(s): 藤原圭志、古田 康、青木和香恵、本間明宏
  • Journal Title: Facial N Res JPN Volume: 38 Pages: 147-149
  • Peer Reviewed
• [Journal Article] Clinical Characteristics and Treatment Outcomes for Patients With External Auditory Canal Cholesteatoma. (2018)
  • Author(s): Morita S, Nakamaru Y, Fukuda A, Fujiwara K, Hoshino K, Homma A
  • Journal Title: Otol Neurotol Volume: 39ページ Issue: 2 Pages: 189-195
  • DOI: 10.1097/mao.0000000000001659
  • Peer Reviewed
• [Journal Article] Oncocytoma of the Parotid Gland with Facial Nerve Paralysis (2018)
  • Author(s): Hamada S, Fujiwara K, Hatakeyama H, Homma A
  • Journal Title: Case Rep Otolaryngol Volume: N/A Pages: 7687951-7687951
  • DOI: 10.1155/2018/7687951
  • Peer Reviewed
• [Journal Article] Comparison of the University of Pittsburgh staging system and the eighth edition of the American Joint Committee on Cancer TNM classification for the prognostic evaluation of external auditory canal cancer. (2018)
  • Author(s): Morita S, Mizumachi T, Nakamaru Y, Sakashita T, Kano S, Hoshino K, Fukuda A, Fujiwara K, Homma A.
  • Journal Title: Int J Clin Oncol. Volume: 23 Issue: 6 Pages: 1029-1037
  • DOI: 10.1007/s10147-018-1314-3
  • NAID: 120006650534
  • Peer Reviewed
• [Journal Article] Anti-mumps IgM antibody positive rate with sudden sensorineural hearing loss using second-generation enzyme immunoassay: A retrospective, multi-institutional investigation in Hokkaido, Japan. (2017)
  • Author(s): Atsushi Fukuda, Shinya Morita, Yuji Nakamaru, Kimiko Hoshino, Keishi Fujiwara, Shigeru Akazawa, Tomohiro Sakashita, Nobuyuki Obara, Akihiro Homma
  • Journal Title: Auris Nasus Larynx Volume: 印刷中 Issue: 5 Pages: 911-915
  • DOI: 10.1016/j.anl.2017.11.016
  • NAID: 120006727590
  • Peer Reviewed
• [Journal Article] Evaluation of Vestibular Functions in Patients with Vogt-Koyanagi-Harada Disease (2017)
  • Author(s): Keishi Fujiwara, Shinya Morita, Kimiko Hoshino, Atsushi Fukuda, Yuji Nakamaru, Akihiro Homma
  • Journal Title: Audiol Neurotol Volume: 22 Issue: 3 Pages: 190-195
  • DOI: 10.1159/000481426
  • Peer Reviewed
• [Journal Article] イピリムマブ使用中に発症した顔面神経麻痺の2症例 (2017)
  • Author(s): 藤原圭志、松浦真理、福田 諭
  • Journal Title: Facial N Res JPN Volume: 37 Pages: 115-117
  • Peer Reviewed
• [Journal Article] Value of T1-weighted Magnetic Resonance Imaging in Cholesteatoma Detection (2017)
  • Author(s): Atsushi Fukuda, Shinya Morita, Taisuke Harada, Keishi Fujiwara, Kimiko Hoshino, Yuji Nakamaru, Akihiro Homma
  • Journal Title: Otology & neurotology Volume: 38 Issue: 10 Pages: 1440-1444
  • DOI: 10.1097/mao.0000000000001558
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The clinical features and prognosis of mumps-associated hearing loss: a retrospective, multi-institutional investigation in Japan. (2017)
  • Author(s): Morita S, Fujiwara K, Fukuda A, Fukuda S, Nishio SY, Kitoh R, Hato N, Ikezono T, Ishikawa K, Kaga K, Matsubara A, Matsunaga T, Murata T, Naito Y, Nishizaki K, Ogawa K, Sano H, Sato H, Sone M, Suzuki M, Takahashi H, Tono T, Yamashita H, Yamasoba T, Usami SI
  • Journal Title: Acta Otolaryngol Volume: 印刷中 Issue: sup565 Pages: S44-S47
  • DOI: 10.1080/00016489.2017.1290826
  • Peer Reviewed
• [Journal Article] 顔面神経麻痺の臨床的評価法 (2017)
  • Author(s): 藤原圭志、古田 康
  • Journal Title: ENTONI Volume: 203 Pages: 7-15
• [Journal Article] 顔面神経麻痺のマニュアル・セラピー－STの立場から－ (2017)
  • Author(s): 山本奈緒子、古田 康、藤原圭志
  • Journal Title: ENTONI Volume: 203 Pages: 22-28
• [Journal Article] The Short- and Long-Term Outcome of Intratympanic Steroid Therapy as a Salvage Treatment for Acute Low-Tone Sensorineural Hearing Loss without Episodes of Vertigo. (2016)
  • Author(s): Shinya Morita, Yuji Nakamaru, Keishi Fujiwara, Keiji Iizuka, Masayori Masuya, Akihiro Homma, Atsushi Fukuda, Satoshi Fukuda
  • Journal Title: Audiol Neurotol Volume: 21 Issue: 3 Pages: 132-140
  • DOI: 10.1159/000444577
  • NAID: 120006313436
  • Peer Reviewed
• [Journal Article] Time course of downbeat positioning nystagmus in familial hemiplegic migraine type 1 treated with acetazolamide (2016)
  • Author(s): Masanobu Suzuki, Keishi Fujiwara, Takashi Tsubuku, Ichiro Yabe, Hidenao Sasaki, Satoshi Fukuda
  • Journal Title: J Neurol Sci Volume: 368 Pages: 206-208
  • DOI: 10.1016/j.jns.2016.07.020
  • Peer Reviewed
• [Journal Article] シンポジウム1 顔面神経麻痺の評価up-to-date 後遺症の評価 (2016)
  • Author(s): 藤原圭志、古田 康、福田 諭
  • Journal Title: Facial N Res JPN Volume: 36 Pages: 15-17
  • Peer Reviewed
• [Journal Article] 当科における顔面神経麻痺患者に対するメーキャップ治療の現況 (2016)
  • Author(s): 藤原圭志、古田 康、青木和香恵、福田 諭
  • Journal Title: Facial N Res JPN Volume: 36 Pages: 152-153
  • Peer Reviewed
• [Journal Article] 顔面神経麻痺をきたした耳下腺oncocytomaの1例 (2016)
  • Author(s): 浜田誠二郎、藤原圭志、畠山博充、本間明宏、福田 諭
  • Journal Title: Facial N Res JPN Volume: 36 Pages: 191-193
  • Peer Reviewed
• [Presentation] 顔面神経麻痺患者に対するメーキャップ治療の精神面に対する効果 (2018)
  • Author(s): 藤原圭志、古田 康、青木和香恵、本間明宏
  • Organizer: 第４１回日本顔面神経学会
• [Presentation] vHITを用いた聴神経腫瘍症例の垂直半規管機能評価 (2018)
  • Author(s): 藤原圭志、森田真也、干野季美子、福田 篤、中丸裕爾、本間明宏
  • Organizer: 第２８回耳科学会
• [Presentation] 聴神経腫瘍症例の半規管機能と関連する因子の検討 (2018)
  • Author(s): 藤原圭志、赤松明樹、本間明宏
  • Organizer: 第７７回めまい平衡医学会
• [Presentation] Evaluation of vestibular functions in patients with Vogt-Koyanagi-Harada disease (2018)
  • Author(s): Keishi Fujiwara, Shinya Morita, Kimiko Hoshino, Atsushi Fukuda, Yuji Nakamaru, Akihiro Homma
  • Organizer: The 9th EAONO Instructional Workshop
  • Int'l Joint Research
• [Presentation] Vogt-小柳-原田病における平衡機能障害に関する検討 (2017)
  • Author(s): 藤原圭志、森田真也、干野季美子、福田 篤、中丸裕爾、福田 諭
  • Organizer: 第１１８回日本耳鼻咽喉科学会総会
• [Presentation] イピリムマブ使用中に発症した顔面神経麻痺の2症例 (2017)
  • Author(s): 藤原圭志、福田 諭
  • Organizer: 第４０回日本顔面神経学会
• [Presentation] 当科におけるvideo Head Impulse Testの使用経験 (2017)
  • Author(s): 藤原圭志、柳 紘子、森田真也、干野季美子、福田 篤、中丸裕爾、本間明宏
  • Organizer: 第２１６回日本耳鼻咽喉科学会北海道地方会
• [Presentation] 外耳・中耳病変を有する症例の半規管機能評価 －video Head Impulse Testを用いて－ (2017)
  • Author(s): 藤原圭志、本間明宏
  • Organizer: 第７６回めまい平衡医学会
• [Presentation] Factors affecting the effect of rehabilitation therapy for synkinesis as a sequela to facial nerve palsy (2017)
  • Author(s): Keishi Fujiwara, Yasushi Furuta Shinya Morita, Atsushi Fukuda, Akihiro Homma
  • Organizer: 4th Congress of European ORL-HNS
  • Int'l Joint Research
• [Presentation] 両側半規管麻痺を呈した大動脈炎症候群の1例 (2016)
  • Author(s): 藤原圭志、福田 諭
  • Organizer: 第７５回めまい平衡医学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-10-27
• [Presentation] 顔面神経麻痺患者に対するメーキャップ治療 (2016)
  • Author(s): 藤原圭志、古田 康、青木和香恵、福田 諭
  • Organizer: 第２６回日本耳科学会
  • Place of Presentation: ホテル国際21（長野県長野市）
  • Year and Date: 2016-10-06
• [Presentation] A case of oculostapedial synkinesis without history of facial nerve palsy -a rare manifestation of tinnitus- (2016)
  • Author(s): Keishi Fujiwara, Yasushi Furuta, Shinya Morita, Atsushi Fukuda, Akihiro Homma, Takatsugu Mizumachi, Satoshi Fukuda
  • Organizer: 10th International Conference on Cholesteatoma and Ear Surgery
  • Place of Presentation: Edinburgh,UK
  • Year and Date: 2016-06-05
  • Int'l Joint Research
• [Presentation] シンポジウム 1 顔面神経麻痺の評価up-to-date (2016)
  • Author(s): 藤原圭志
  • Organizer: 第３９回日本顔面神経学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-05-26
• [Presentation] 当科における顔面神経麻痺患者に対するメーキャップ治療の現況 (2016)
  • Author(s): 藤原圭志、古田 康、青木和香恵、福田 諭
  • Organizer: 第３９回日本顔面神経学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2016-05-26