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Combination of molecular-targeted therapy with peptide vaccine

Research Project

Project/Area Number 16K20223
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionAsahikawa Medical College

Principal Investigator

Kumai Takumi  旭川医科大学, 医学部, 特任講師 (00596306)

Research Collaborator HARABUCHI Yasuaki  
KOBAYASHI Hiroya  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords頭頸部癌 / 腫瘍免疫 / ペプチドワクチン / アジュバント / 分子標的薬 / 腫瘍抗原
Outline of Final Research Achievements

Based on the clinical success of immune checkpoint inhibitors, immunotherapy has been considered as a novel pillar of cancer treatment. In this study, we examine the synergistic effect of molecular-targeted therapy with peptide vaccine. The blockade of EGFR or c-Met induced tumoral MHC expression or TGF-b, an immunosuppressive cytokine, suppression, respectively. These treatments augmented the recognition and cytotoxicity of peptide-reactive CD4 T cells to head and neck squamous cell carcinoma cells and nasal NK/T cell lymphoma cells.

Academic Significance and Societal Importance of the Research Achievements

本研究で新たな癌免疫療法の基盤が確立されたことで、PD-1阻害薬では効果不十分であった症例にもさらなる免疫細胞による抗腫瘍効果が期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (13 results)

All 2019 2018 2017

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results) Presentation (9 results) (of which Int'l Joint Research: 7 results,  Invited: 2 results)

  • [Journal Article] Extranodal Natural Killer/T-Cell Lymphoma, Nasal Type: Basic Science and Clinical Progress2019

    • Author(s)
      Harabuchi Yasuaki、Takahara Miki、Kishibe Kan、Nagato Toshihiro、Kumai Takumi
    • Journal Title

      Frontiers in Pediatrics

      Volume: 7 Pages: 141-141

    • DOI

      10.3389/fped.2019.00141

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting phosphorylated p53 to elicit tumor-reactive T helper responses against head and neck squamous cell carcinoma2018

    • Author(s)
      Ohara Kenzo、Ohkuri Takayuki、Kumai Takumi、Nagato Toshihiro、Nozaki Yui、Ishibashi Kei、Kosaka Akemi、Nagata Marino、Harabuchi Shohei、Ohara Mizuho、Oikawa Kensuke、Aoki Naoko、Harabuchi Yasuaki、Celis Esteban、Kobayashi Hiroya
    • Journal Title

      OncoImmunology

      Volume: 7 Issue: 9 Pages: e1466771-e1466771

    • DOI

      10.1080/2162402x.2018.1466771

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Peptide vaccines in cancer ― old concept revisited2017

    • Author(s)
      Takumi Kumai, Hiroya Kobayashi, Yasuaki Harabuchi and Esteban Celis
    • Journal Title

      Current opinion in immunology

      Volume: 45 Pages: 1-7

    • DOI

      10.1016/j.coi.2016.11.001

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Optimization of Peptide Vaccines to Induce Robust Antitumor CD4 T-cell Responses2017

    • Author(s)
      Takumi Kumai, Sujin Lee, Hyun-Il Cho, Hussein Sultan, Hiroya Kobayashi, Yasuaki Harabuchi, and Esteban Celis
    • Journal Title

      Cancer Immunology Research

      Volume: 5 Pages: 1-12

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Sustained persistence of IL-2 signaling enhances the antitumor effect of peptide vaccines2019

    • Author(s)
      Kumai, T.//Sultan, H.//Harabuchi, Y.//Celis, E.
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses2018

    • Author(s)
      Kumai, T.//Sultan, H.//Kobayashi, H.//Harabuchi, Y.//Celis, E.
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The identification of extranodal NK/T cell lymphoma, nasal type-associated antigen for helper T cell-based immunotherapy2018

    • Author(s)
      Kumai T.//Komatsuda, H.// Araki, D.//Nagato, T.//Kishibe, K.//Takahara, M.//Hayashi, T.//Harabuchi, Y.
    • Organizer
      International Conference on EBV & KSHV
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ヘルパーペプチドワクチンの実用化に向けたアジュバントの開発2018

    • Author(s)
      熊井琢美//大原賢三//野崎 結//長門利純//林 達哉//小林博也//原渕保明
    • Organizer
      日本耳鼻咽喉科免疫アレルギー学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Optimization of peptide vaccines to induce robust antitumor CD4 T-cell responses2018

    • Author(s)
      Kumai T.//Sultan, H.//Kobayashi, H.//Harabuchi, Y.//Celis, E.
    • Organizer
      American Association for Cancer Research Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] The identification of nasal NK/T-cell lymphoma-associated antigens for helper T cell-based immunotherapy2017

    • Author(s)
      Kumai, T.//Nagato, T,//Takahara, M.//Katada, A.//,Hayashi, T.//Harabuchi, Y.
    • Organizer
      53rd Korean Rhinologic Society Annual Congress
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Antitumor responses by HER-3-reactive CD4 helper T cells combined with HER inhibitor in vitro2017

    • Author(s)
      Kumai, T.//Hayashi, T.//Kobayashi, H.//Harabuchi, Y.
    • Organizer
      The International Federation of ORL Societies (IFOS) 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] EBウイルス陽性鼻性NK/T細胞リンパ腫にたいするペプチドワクチン療法の開発2017

    • Author(s)
      熊井琢美//長門利純//林 達哉/小林博也//原渕保明
    • Organizer
      日本ウイルス学会
    • Related Report
      2017 Research-status Report
  • [Presentation] The identification of nasal NK/T-cell lymphoma-associated antigens for helper T cell-based immunotherapy2017

    • Author(s)
      Takumi Kumai, Toshihiro Nagato, Miki Takahara, Akihiro Katada, Tatsuya Hayashi, Yasuaki Harabuchi
    • Organizer
      53rd Korean Rhinologic Society Annual Congress
    • Place of Presentation
      ソウル、韓国
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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