Interpretation about the mechanism and the function of D-amino acid, and it`s association with chronic inflammations
| Project/Area Number |
16K20225
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | D-アミノ酸 / D-アスパラギン酸 / 慢性炎症 / 好酸球性炎症 / 鼻ポリープ / 声帯ポリープ / 喉頭癌 / 乳頭腫 / Dアミノ酸 / 癌腫 / アレルギー性炎症 / 好酸球浸潤 / 老化 / ストレス / タンパク質 |
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| Outline of Final Research Achievements |
While it is considered that D-amino acids were eliminated from living organisms, we demonstrated the expression of D-amino acid, especially D-aspartic acid, in various tissues of the otorhinolaryngological field. D-aspartic acid expressed strongly in nasal polyps of eosinophilic chronic rhinosinusitis patients in the recurrence case. It was also revealed that D-aspartic acid expressed strongly in the tissue of vocal cord nodule, squamous papilloma and laryngeal cancer. It was seemed that D-aspartic acid is correlated with the pathogenesis of these diseases.
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| Academic Significance and Societal Importance of the Research Achievements |
いままで生体内に存在しないと考えられ、その機能的役割も不明確であったD-アミノ酸が様々な疾患組織中に発現していることが示された。癌腫などの細胞が異常増殖している部位や、難治性炎症が起きていると考えられる鼻ポリープ組織や声帯結節に多く発現することが明らかとなった。この発現機序をさらに研究することにより、疾患の治療や予防に役立てることができる可能性がある。
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Report
(5 results)
Research Products
(2 results)
