Investigation of a novel prognostic serum marker in head and neck squamous cell carcinoma

• Project/Area Number: 16K20229
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Otorhinolaryngology
• Research Institution: Chiba University
• Principal Investigator: Katada Koji 千葉大学, 大学院医学研究院, 助教 (60596112)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 頭頸部癌 / 癌 / 蛋白質 / プロテオーム

Outline of Final Research Achievements

We searched plectin which is expressed in head and neck cancer tissue in serum, but could not identify obvious protein or peptide with significant difference in head and neck cancer patient. However, we validated the evidence for integrin family (ITGB1) which is associated with plecitn in head and neck cancer tissues, and we found that it is controlled by microRNAs functioning as tumor suppressor genes or oncogenes. We also discovered that ITB1 is involved in the prognosis of patients with head and neck cancer and migration, proliferation and invasion of head and neck cancer cells.

Research Products

• [Journal Article] Passenger strand of miR-145-3p acts as a tumor-suppressor by targeting MYO1B in head and neck squamous cell carcinoma (2018)
  • Author(s): Yamada Y, Koshizuka K, Hanazawa T, Kikkawa N, Okato A, Idichi T, Arai T, Sugawara S, Katada K, Okamoto Y, Seki N.
  • Journal Title: International Journal of Oncology Volume: 52 Pages: 166-178
  • DOI: 10.3892/ijo.2017.4190
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of integrin &#x3B2;1-mediated oncogenic signalling by the antitumor <i>microRNA-29</i> family in head and neck squamous cell carcinoma (2017)
  • Author(s): Koshizuka Keiichi、Kikkawa Naoko、Hanazawa Toyoyuki、Yamada Yasutaka、Okato Atsushi、Arai Takayuki、Katada Koji、Okamoto Yoshitaka、Seki Naohiko
  • Journal Title: Oncotarget Volume: 9 Issue: 3 Pages: 3663-3676
  • DOI: 10.18632/oncotarget.23194
  • Peer Reviewed / Open Access
• [Journal Article] Regulation of ITGA3 by the anti-tumor miR-199 family inhibits cancer cell migration and invasion in head and neck cancer (2017)
  • Author(s): Koshizuka Keiichi、Hanazawa Toyoyuki、Kikkawa Naoko、Arai Takayuki、Okato Atsushi、Kurozumi Akira、Kato Mayuko、Katada Koji、Okamoto Yoshitaka、Seki Naohiko
  • Journal Title: Cancer Science Volume: 108 Issue: 8 Pages: 1681-1692
  • DOI: 10.1111/cas.13298
  • Peer Reviewed / Open Access
• [Journal Article] Deep sequencing-based microRNA expression signatures in head and neck squamous cell carcinoma: dual strands of pre-miR-150 as antitumor miRNAs. (2017)
  • Author(s): Koshizuka K, Hanazawa T, Fukumoto I, Kikkawa N, Okamoto Y, Seki N.
  • Journal Title: Oncotarget Volume: 印刷中 Issue: 18 Pages: 30288-30304
  • DOI: 10.18632/oncotarget.16327
  • Peer Reviewed / Open Access