| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
|
|---|
| Outline of Final Research Achievements |
TRPM8 is a cold sensing channel activated by cold stimulation and expressed in a subset of sensory neurons. The aim of this study was to clarify the mechanism of nasal hyperreactivity through the expression analysis and functional analysis of TRPM8 in nasal cavity. Using immunohistochemistry and real-time PCR, we found that the expression of TRPM8 increased in the trigeminal ganglia of allergic rhinitis model mice and aging model mice. In addition, behavior test revealed that both model mice sneezed more than normal mice after nasal administration of TRPM8 agonist menthol. It is suggested that TRPM8 may play an important role in pathogenesis of nasal hyperreactivity.
|
