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The involvment of HERV in lymphocyte infitration of nasopharyngeal carcinoma

Research Project

Project/Area Number 16K20235
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Otorhinolaryngology
Research InstitutionKanazawa University

Principal Investigator

AGA Mitsuharu  金沢大学, 医学系, 協力研究員 (90756230)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords上咽頭癌 / LMP1 / EBV / REST/NRSF / HERV / 癌
Outline of Final Research Achievements

In the present study we showed a panel of LMP1 expressing cell lines had high expression of REST compared with not. The enhancement of REST by LMP1 was regulated by activation of REST promoter, not blockade of ubiquitin-proteasome pathway. Furthermore, we demonstrated that REST works as transcriptional suppressor of CSC marker in NPC cells. Moreover, it enhances invasive potential of NPC cells. The series of findings indicate that REST functions as transcriptional repressor and involved with invasive potential of NPC expressing EBV oncogene.

Academic Significance and Societal Importance of the Research Achievements

以上のことから、RESTは転写抑制因子として上咽頭癌細胞の癌幹細胞化に関わっており、上咽頭癌の浸潤能に寄与することが示唆された。以前、我々はLMP1が誘導する転写因子がエクソソームとよばれる細胞外小胞を介して周囲の細胞に運ばれることを示した。今後RESTがエクソソームを介して周囲の細胞に影響を及ぼすか検討予定である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (4 results)

All 2018 2017

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Siah-1 is associated with expression of hypoxia-inducible factor-1α in oral squamous cell carcinoma.2017

    • Author(s)
      Aga M, Kondo S, Wakisaka N, Moriyama-Kita M, Endo K, Nakanishi Y, Murono S, Sugimoto H, Ueno T, Yoshizaki T.
    • Journal Title

      Auris Nasus Larynx

      Volume: 44 Issue: 2 Pages: 213-219

    • DOI

      10.1016/j.anl.2016.06.007

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] EBV癌タンパクLMP1陽性癌細胞におけるRE1-silencing transcription factor (REST)の転写因子としての役割2018

    • Author(s)
      阿河光治、近藤悟、吉崎智一
    • Organizer
      北陸腸内細菌研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] A retrospective study of intra-arterial chemotherapy with concurrent radiotherapy for resectable locally advanced oropharyngeal carcinoma2018

    • Author(s)
      Mitsuharu AGA, Tomokazu YOSHIZAKI
    • Organizer
      IFHNOS
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of cell competition in EBV-positive nasopharyngeal carcinoma2017

    • Author(s)
      Mitsuharu Aga, Tomokazu Yoshizaki
    • Organizer
      The International Federation of ORL Societies
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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